Alicyclic-Amine-Derived Imine-BF3 Complexes: Easy-to-Make Building Blocks for the Synthesis of Valuable α-Functionalized Azacycles,Angewandte Chemie International Edition

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Alicyclic-Amine-Derived Imine-BF3 Complexes: Easy-to-Make Building Blocks for the Synthesis of Valuable α-Functionalized Azacycles
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-11-01 , DOI: 10.1002/anie.202313247
Subhradeep Dutta ₁ , Jae Hyun Kim _{1,

2} , Kamal Bhatt ₁ , Dillon R L Rickertsen ₁ , Khalil A Abboud ₃ , Ion Ghiviriga ₄ , Daniel Seidel ₁

Affiliation

Imine-BF₃ complexes derived from alicyclic amines represent novel building blocks that are readily prepared in a single synthetic operation. These complexes engage with a wide range of organometallic nucleophiles to afford α-functionalized azacycles, typically under non-cryogenic conditions. The in situ preparation of imine-BF₃ complexes provides access to α-functionalized morpholines and piperazines directly from their parent amines.

中文翻译：

脂环胺衍生的亚胺-BF3 配合物：用于合成有价值的α官能化氮杂环素的易制备构建单元

源自脂环胺的亚胺-BF₃ 复合物代表了新型合成单元，可在一次合成操作中轻松制备。这些复合物与多种有机金属亲核试剂结合，通常在非低温条件下获得α官能团化的氮杂环。亚胺-BF₃ 复合物的原位制备提供了直接从其母胺获得α官能化吗嗪和哌嗪的机会。

更新日期：2023-11-01

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