Photoenzymatic Enantioselective Synthesis of Oxygen-Containing Benzo-Fused Heterocycles,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Photoenzymatic Enantioselective Synthesis of Oxygen-Containing Benzo-Fused Heterocycles
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-10-29 , DOI: 10.1002/anie.202311762
Changtong Zhu ₁ , Zhenbo Yuan ₁ , Zhiwei Deng ₁ , Dejing Yin ₁ , Yan Zhang ₂ , Jingwen Zhou ₃ , Yijian Rao ₁

Affiliation

Combining photocatalysis and biocatalysis allows for the repurposing of the ‘ene’-reductase enzyme GluER to achieve the enantioselective synthesis of benzo-fused heterocycles, and various benzoxepinones, chromanone and indanone were specifically afforded in high yields with good to excellent enantioselectivities after protein engineering of GluER.

中文翻译：