<br>用于诊断周围神经病变的可调谐水凝胶电子器件,Advanced Materials

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用于诊断周围神经病变的可调谐水凝胶电子器件
Advanced Materials ( IF 27.4 ) Pub Date : 2023-10-31 , DOI: 10.1002/adma.202308831
Ganguang Yang ₁ , Yijia Hu ₁ , Wei Guo ₁ , Wei Lei ₂ , Wei Liu ₃ , Guojun Guo ₂ , ChaoFan Geng ₂ , Yutian Liu ₂ , Hao Wu _{1,

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以患者数量迅速增加为特征的周围神经病通常通过分析从刺激记录设备获得的肌电图信号来诊断。然而，现有的商业电极难以实现与皮肤的保形接触和温和的分离，从而极大地损害了刺激/记录性能。在这里，这项工作开发了带有聚天冬氨酸修饰的多巴胺/乙基离子液体水凝胶（PDEH）的皮肤贴片作为刺激/记录装置来捕获肌电图信号以诊断周围神经病。通过一步电场处理触发，水凝胶实现了粘附力的快速和大范围调节，并显着增强了机械性能。此外，与银液态金属（SLM）层组装的水凝胶贴片表现出优异的电荷注入和低接触阻抗，能够捕获高保真肌电图。这项工作进一步验证了水凝胶装置准确诊断感觉神经、运动神经和混合神经周围神经病变的可行性。针对身体的各个部位，如手指、老年人松弛的皮肤、多毛的皮肤和儿童脆弱的皮肤，这项工作调节PDEH-SLM装置的粘附力，以建立紧密的装置/皮肤界面或确保良性去除。值得注意的是，水凝胶贴片可以在这些临床病例中实现神经损伤的精确诊断，同时提供更有效的刺激/记录性能的额外优势。这些贴片为未来神经病的诊断和康复提供了一种有前景的替代方案。

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Tunable Hydrogel Electronics for Diagnosis of Peripheral Neuropathy

Peripheral neuropathy characterized by rapidly increasing numbers of patients is commonly diagnosed via analyzing electromyography signals obtained from stimulation-recording devices. However, existing commercial electrodes have difficulty in implementing conformal contact with skin and gentle detachment, dramatically impairing stimulation/recording performances. Here, this work develops on-skin patches with polyaspartic acid-modified dopamine/ethyl-based ionic liquid hydrogel (PDEH) as stimulation/recording devices to capture electromyography signals for the diagnosis of peripheral neuropathy. Triggered by a one-step electric field treatment, the hydrogel achieves rapid and wide-range regulation of adhesion and substantially strengthened mechanical performances. Moreover, hydrogel patches assembled with a silver-liquid metal (SLM) layer exhibit superior charge injection and low contact impedance, capable of capturing high-fidelity electromyography. This work further verifies the feasibility of hydrogel devices for accurate diagnoses of peripheral neuropathy in sensory, motor, and mixed nerves. For various body parts, such as fingers, the elderly's loose skin, hairy skin, and children's fragile skin, this work regulates the adhesion of PDEH-SLM devices to establish intimate device/skin interfaces or ensure benign removal. Noticeably, hydrogel patches achieve precise diagnoses of nerve injuries in these clinical cases while providing extra advantages of more effective stimulation/recording performances. These patches offer a promising alternative for the diagnosis and rehabilitation of neuropathy in future.

更新日期：2023-10-31

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