Rhubarb palmatum L., Polygonum multijiorum Thunb., and Polygonum cuspidatum Sieb. Et Zucc. are traditional Chinese medicines that have been used for thousands of years. They are formulated into various preparations and are widely used. Emodin is a traditional Chinese medicine monomer and the main active ingredient in Rhubarb palmatum L., Polygonum multijiorum Thunb., and Polygonum cuspidatum Sieb. Et Zucc. Modern research shows that it has a variety of pharmacological effects, including promoting lipid and glucose metabolism, osteogenesis, and anti-inflammatory and anti-autophagy effects. Research on the toxicity and pharmacokinetics of emodin can promote its clinical application. This review aims to provide a basis for further development and clinical research of emodin in the treatment of metabolic diseases. We performed a comprehensive summary of the pharmacology and molecular mechanisms of emodin in treating metabolic diseases by searching databases such as Web of Science, PubMed, ScienceDirect, and CNKI up to 2023. In addition, this review also analyzes the toxicity and pharmacokinetics of emodin. The results show that emodin mainly regulates AMPK, PPAR, and inflammation-related signaling pathways, and has a good therapeutic effect on obesity, hyperlipidemia, non-alcoholic fatty liver disease, diabetes and its complications, and osteoporosis. In addition, controlling toxic factors and improving bioavailability are of great significance for its clinical application.

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大黄素治疗代谢性疾病的药理作用及分子机制研究进展

鸡掌大黄L。, 何首乌桑布.,和虎杖西布。等祖克。是已经使用了数千年的传统中药。它们被配制成各种制剂并被广泛使用。大黄素是一种中药单体，是中药的主要活性成分。鸡掌大黄L。, 何首乌桑布.,和虎杖西布。等祖克。现代研究表明，它具有多种药理作用，包括促进脂质和糖代谢、成骨作用以及抗炎和抗自噬作用。对大黄素的毒性和药代动力学的研究可以促进其临床应用。本综述旨在为大黄素治疗代谢性疾病的进一步开发和临床研究提供依据。我们通过检索截至2023年的Web of Science、PubMed、ScienceDirect、CNKI等数据库，对大黄素治疗代谢性疾病的药理学和分子机制进行了全面总结。此外，本文还分析了大黄素的毒性和药代动力学。结果表明，大黄素主要调节AMPK、PPAR以及炎症相关信号通路，对肥胖、高脂血症、非酒精性脂肪肝、糖尿病及其并发症、骨质疏松症等具有良好的治疗作用。此外，控制毒性因素、提高生物利用度对其临床应用具有重要意义。