Background: Terminalia chebula (T. chebula) comprising chebulinic acid as its principle active constituent is used to cure various diseases. T. chebula and chebulinic acid are used as antimicrobial, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, antimutagenic, radioprotective, cardioprotective, antiproliferative, antiarthritic, anticaries, and so on. Objective: The objective of this current study is to give an overview of the recent literature and patents of T. chebula and chebulinic acid including methods of its isolation/extraction and their application in the prevention of various cancers and other diseases. Methods: Present research and patents highlighting the anti-cancer potential of T. chebula and chebulinic acid have been studied and discussed keeping in view the scientific novelty and impact. Results: Both T. chebula and chebulinic acid are currently being explored for their anticancer potential in vitro and in vivo. They are either incorporated alone or in combination with other plants or drugs to show their activity and many clinical trials are also going on various potentials of the plant and chebulinic acid. Novel extraction techniques are also explored and patented. Efforts are being made to improve the bioavailability by developing Novel herbal drug delivery systems of the plant extract or chebulinic acid itself. Conclusion: Anti-cancer potential of T. chebula and chebulinic acid may be well established by promising clinical trials and may open new interventions in various tumors. Clinical trials in conjunction with standard therapies are required to explore and validate the actual potential of T. chebula and chebulinic acid respectively.

中文翻译：

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Chebulinic Acid：一种早期抗癌剂

背景：以车布林酸为主要活性成分的榄仁树（T. chebula）用于治疗多种疾病。T. chebula 和 chebulinic Acid 用作抗菌、抗氧化剂、抗糖尿病、抗炎、保肝、抗突变、辐射防护、心脏保护、抗增殖、抗关节炎、防龋齿等。目的：本研究的目的是概述 T. chebula 和 chebulinic 酸的最新文献和专利，包括其分离/提取方法及其在预防各种癌症和其他疾病中的应用。方法：对当前强调 T. chebula 和 chebulinic 酸抗癌潜力的研究和专利进行了研究和讨论，同时考虑到科学新颖性和影响力。结果：目前正在探索 T. chebula 和 chebulinic 酸的体外和体内抗癌潜力。它们可以单独使用，也可以与其他植物或药物结合使用，以显示其活性，并且许多临床试验也正在进行中，以了解植物和鹅卵石酸的各种潜力。还探索了新的提取技术并获得了专利。人们正在努力通过开发植物提取物或chebulinic酸本身的新型草药给药系统来提高生物利用度。结论：T. chebula 和 chebulinic 酸的抗癌潜力可能通过有前景的临床试验得到充分证实，并可能为各种肿瘤开辟新的干预措施。需要结合标准疗法进行临床试验，以分别探索和验证 T. chebula 和 chebulinic 酸的实际潜力。