PEGylated Dmoc phosphoramidites for sensitive oligodeoxynucleotide synthesis,Organic & Biomolecular Chemistry

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PEGylated Dmoc phosphoramidites for sensitive oligodeoxynucleotide synthesis
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2023-10-31 , DOI: 10.1039/d3ob01495a
Komal Chillar ₁ , Yipeng Yin ₁ , Alexander Apostle ₁ , Shiyue Fang ₁

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Sensitive oligodeoxynucleotides (ODNs) can be synthesized using Dmoc phosphoramidites, but only short ODNs were demonstrated. Here, we report the synthesis of much longer ODNs, which was made possible by the use of PEGylated Dmoc (pDmoc) phosphoramidites. The longer ODNs synthesized include those containing the sensitive 4acC epigenetic modification recently discovered in nature.

中文翻译：

聚乙二醇化 Dmoc 亚磷酰胺，用于灵敏的寡脱氧核苷酸合成

敏感的寡脱氧核苷酸（ODN）可以使用 Dmoc 亚磷酰胺合成，但仅证明了短 ODN。在这里，我们报道了更长的 ODN 的合成，这是通过使用聚乙二醇化 Dmoc （pDmoc）亚磷酰胺实现的。合成的较长的 ODN 包括那些包含最近在自然界中发现的敏感 4acC 表观遗传修饰的 ODN。

更新日期：2023-11-03

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