The cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recently, various mechanosensors have been identified, and their contributions to muscle mechanoreflex have been actively investigated. Nevertheless, the mechanosensitive channels responsible for this muscular reflex remain largely unknown. This review discusses progress in our understanding of muscle mechanoreflex under healthy conditions, focusing on mechanosensitive channels.

运动过程中心血管反应得到适当调节，以满足活跃肌肉的代谢需求。运动加压反射是通过活跃骨骼肌中的机械和代谢刺激激活的细纤维肌肉传入的神经反馈机制。这种反射的机械部分被称为骨骼肌机械感受反射。其第一步需要由机械传感器介导的机械转导，将机械刺激转化为生物信号。最近，各种机械传感器已被识别，并且它们对肌肉机械感受反射的贡献已被积极研究。然而，负责这种肌肉反射的机械敏感通道仍然很大程度上未知。这篇综述讨论了我们对健康条件下肌肉机械感觉反射的理解进展，重点关注机械敏感通道。