Tuning Blood–Material Interactions to Generate Versatile Hemostatic Powders and Gels,Advanced Healthcare Materials

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Tuning Blood–Material Interactions to Generate Versatile Hemostatic Powders and Gels
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-10-28 , DOI: 10.1002/adhm.202301945
Xueru Wang ₁ , Kai Yuan ₂ , Yang Su ₁ , Xiaoyue Li ₁ , Limin Meng ₃ , Nana Zhao ₁ , Yang Hu ₁ , Feng Duan ₂ , Fu-Jian Xu ₁

Affiliation

Polymer-based hemostatic materials/devices have been increasingly exploited for versatile clinical scenarios, while there is an urgent need to reveal the rational design/facile approach for procoagulant surfaces through regulating blood–material interactions. In this work, degradable powders (PLPS) and thermoresponsive gels (F127-PLPS) are readily developed as promising hemostatic materials for versatile clinical applications, through tuning blood–material interactions with optimized grafting of cationic polylysine: the former is facilely prepared by conjugating polylysine onto porous starch particle, while F127-PLPS is prepared by the simple mixture of PLPS and commercial thermosensitive polymer. In vitro and in vivo results demonstrate that PLPS2 with the optimal-/medium content of polylysine grafts achieve the superior hemostatic performance. The underlying procoagulant mechanism of PLPS2 surface is revealed as the selective fibrinogen adsorption among the competitive plasma-protein-adsorption process, which is the foundation of other blood–material interactions. Moreover, in vitro results confirm the achieved procoagulant surface of F127-PLPS through optimal PLPS2 loading. Together with the tunable thermoresponsiveness, F127-PLPS exhibits outstanding hemostatic utilization in both femoral-artery-injury and renal-artery-embolization models. The work thereby pioneers an appealing approach for generating versatile polymer-based hemostatic materials/devices.

中文翻译：

调节血液与材料的相互作用以产生多功能止血粉末和凝胶

基于聚合物的止血材料/装置已越来越多地用于多种临床场景，同时迫切需要通过调节血液与材料的相互作用来揭示促凝血表面的合理设计/简便方法。在这项工作中，通过优化阳离子聚赖氨酸的接枝来调节血液与材料的相互作用，可降解粉末（PLPS）和热敏凝胶（F127-PLPS）很容易被开发为具有多种临床应用前景的止血材料：前者是通过缀合聚赖氨酸轻松制备的F127-PLPS是由PLPS和商业热敏聚合物的简单混合物制备而成。体外和体内结果表明，具有最佳/中等含量聚赖氨酸移植物的PLPS2实现了优异的止血性能。 PLPS2表面的潜在促凝血机制被揭示为竞争性血浆-蛋白质吸附过程中的选择性纤维蛋白原吸附，这是其他血液-物质相互作用的基础。此外，体外结果证实了通过最佳 PLPS2 负载实现的 F127-PLPS 促凝血表面。加上可调节的热响应性，F127-PLPS 在股动脉损伤和肾动脉栓塞模型中都表现出出色的止血作用。因此，这项工作开创了一种有吸引力的方法来生成多功能聚合物止血材料/装置。

更新日期：2023-10-28

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