<br>用于开发电化学生物传感器的生物电极设计进展,ACS Measurement Science Au

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用于开发电化学生物传感器的生物电极设计进展
ACS Measurement Science Au ( IF 4.6 ) Pub Date : 2023-10-27 , DOI: 10.1021/acsmeasuresciau.3c00034
Nabajyoti Kalita ₁ , Sudarshan Gogoi ₂ , Shelley D Minteer _{3,

4} , Pranab Goswami ₁

Affiliation

电化学生物传感器的选择性、灵敏度、操作和储存稳定性以及响应时间等关键性能因素主要取决于其关键部件生物电极的功能。生物电极接口的适当设计和制造策略对于实现生物传感器实际应用所需的性能至关重要。从大量文献中可以看到实现这一目标的多方面尝试，这些文献探索了在电极表面上制备、固定和稳定生物识别元件的有效策略，以及通过借助先进材料和技术的生物电极接口。现代社会中生物传感器的商业成功也越来越受到其尺寸（以及便携性）、复用能力以及无线通信技术接口耦合的影响，无线通信技术有利于快速数据传输和实时链接决策过程在医疗保健、农业、食品和环境应用等不同领域。因此，生物电极的制造涉及多个参数的仔细选择和控制，包括生物识别元件、电极材料、电极的形状和尺寸、检测原理以及各种制造策略，包括微尺度和印刷技术。本综述讨论了用于开发电化学生物传感器的生物电极设计和制造的最新趋势。讨论内容包括生物识别元件的类型及其固定策略、信号转导方法、常用的电极制造先进材料和生物电极制造技术，以及用于开发具有商业利益的电化学生物传感器的与现代电子通信技术的设备集成。

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Advances in Bioelectrode Design for Developing Electrochemical Biosensors

The critical performance factors such as selectivity, sensitivity, operational and storage stability, and response time of electrochemical biosensors are governed mainly by the function of their key component, the bioelectrode. Suitable design and fabrication strategies of the bioelectrode interface are essential for realizing the requisite performance of the biosensors for their practical utility. A multifaceted attempt to achieve this goal is visible from the vast literature exploring effective strategies for preparing, immobilizing, and stabilizing biorecognition elements on the electrode surface and efficient transduction of biochemical signals into electrical ones (i.e., current, voltage, and impedance) through the bioelectrode interface with the aid of advanced materials and techniques. The commercial success of biosensors in modern society is also increasingly influenced by their size (and hence portability), multiplexing capability, and coupling in the interface of the wireless communication technology, which facilitates quick data transfer and linked decision-making processes in real-time in different areas such as healthcare, agriculture, food, and environmental applications. Therefore, fabrication of the bioelectrode involves careful selection and control of several parameters, including biorecognition elements, electrode materials, shape and size of the electrode, detection principles, and various fabrication strategies, including microscale and printing technologies. This review discusses recent trends in bioelectrode designs and fabrications for developing electrochemical biosensors. The discussions have been delineated into the types of biorecognition elements and their immobilization strategies, signal transduction approaches, commonly used advanced materials for electrode fabrication and techniques for fabricating the bioelectrodes, and device integration with modern electronic communication technology for developing electrochemical biosensors of commercial interest.

更新日期：2023-10-27

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