Facile Syntheses of a Poly-2-phenylbenzobisthiazole-Based Theranostic Nanoplatform,ACS Applied Polymer Materials

当前位置： X-MOL 学术 › ACS Appl. Polym. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Facile Syntheses of a Poly-2-phenylbenzobisthiazole-Based Theranostic Nanoplatform
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2023-10-27 , DOI: 10.1021/acsapm.3c02073
Lei Xin ₁ , Lei Wang _{2,

3} , Qian Wang ₃ , Jian Meng _{2,

3} , Jinfang Gao ₂ , Ruiping Zhang ₄

Affiliation

Photothermal therapy (PTT) is a therapeutic method emerging in recent years, and the photothermal conversion performance of the photothermal agent directly determines the effect of PTT. Poly-2-phenylbenzobisthiazole (PB) is a type of conjugated polymer with a simple synthesis method. It has good biocompatibility and degradability as well as excellent photothermal properties. However, the poor hydrophilicity of PB limits its application in biomaterials. In this work, a reversed-phase precipitation self-assembly method was used to prepare and obtain well-dispersed PB-based nanoparticles. PB and ferric chloride were first dissolved in N-methylpyrrolidone, after which the mixed solution was added dropwise to an aqueous solution of polyphenol and hyaluronic acids. The polyphenol–metal self-assembly network was complexed with PB molecular chains. The water-soluble nanoparticles PFGH prepared exhibited good photothermal properties and had great potential in the field of PTT.

中文翻译：

基于聚-2-苯基苯并双噻唑的治疗诊断纳米平台的简便合成

光热疗法（PTT）是近年来新兴的治疗方法，光热剂的光热转换性能直接决定PTT的效果。聚2-苯基苯并双噻唑(PB)是一种合成方法简单的共轭聚合物。它具有良好的生物相容性和可降解性以及优异的光热性能。然而PB的亲水性差限制了其在生物材料中的应用。本工作采用反相沉淀自组装方法制备并获得分散良好的PB基纳米粒子。首先将PB和氯化铁溶解在N-甲基吡咯烷酮中，然后将混合溶液滴加到多酚和透明质酸的水溶液中。多酚-金属自组装网络与PB分子链络合。制备的水溶性纳米粒子PFGH表现出良好的光热性能，在PTT领域具有巨大的潜力。

更新日期：2023-10-27

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南