Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing,ACS Applied Materials & Interfaces

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Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-10-27 , DOI: 10.1021/acsami.3c10607
Min Tan _{1,

2} , Jing Zeng _{1,

2} , Fu-Zhong Zhang _{1,

2} , Ye-Tao Zhang _{1,

2} , Hongli Li ₃ , Shu-Ting Fan ₄ , Jia-Xin Wang ₄ , Minglong Yuan ₃ , Bang-Jing Li _{1,

2} , Sheng Zhang ₄

Affiliation

Slow healing of wounds induces great pain in diabetic patients. However, developing new approaches to promote diabetic wound healing is still one of the toughest challenges in the medical field. Here, we constructed a new double-layer hydrogel to effectively regulate reactive oxygen species (ROS) on the wound and promote diabetic wound healing. The inner layer contains glucose oxidase (Gox), ferrocene-modified quaternary ammonium chitosan (Fc-QCs), and poly(β-cyclodextrin) (Pβ-CD), which is used to generate hydroxyl radicals (^•OH) for antibacterial in the early stage of wound healing and collapses gradually. The outer layer is composed of gelatin and dopamine. In the later stage of wound healing, the outer layer contacts the skin, which is beneficial for ROS clearance on the wound. Antibacterial, ROS scavenging, and wound healing experiments have shown that the double-layer hydrogel possesses two-stage ROS regulating properties for programmed diabetic wound healing. In conclusion, it will be one of the most potential dressings for treating diabetic wounds in the future.

中文翻译：

具有葡萄糖激活两阶段活性氧调节特性的双层水凝胶可用于程序性糖尿病伤口愈合

伤口愈合缓慢会给糖尿病患者带来巨大的疼痛。然而，开发促进糖尿病伤口愈合的新方法仍然是医学领域最严峻的挑战之一。在这里，我们构建了一种新型双层水凝胶，可以有效调节伤口上的活性氧（ROS）并促进糖尿病伤口愈合。内层含有葡萄糖氧化酶（Gox）、二茂铁改性季铵壳聚糖（Fc-QCs）和聚（β-环糊精）（Pβ-CD），用于产生羟基自由基（·OH）以发挥抗菌^作用。伤口愈合初期，逐渐塌陷。外层由明胶和多巴胺组成。在伤口愈合后期，外层接触皮肤，有利于伤口上ROS的清除。抗菌、ROS清除和伤口愈合实验表明，双层水凝胶具有两阶段ROS调节特性，可促进糖尿病伤口的程序化愈合。总之，它将成为未来治疗糖尿病伤口最有潜力的敷料之一。

更新日期：2023-10-27

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