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Total Synthesis of the Proposed Structure of Neaumycin B
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-10-27 , DOI: 10.1002/anie.202313186
Sen Zhang 1 , Songming Zhang 2 , Yunlong Fan 1 , Xuhai Zhang 1 , Jing Chen 1 , Chaofan Jin 1 , Sisi Chen 2 , Liang Wang 2 , Quan Zhang 1 , Yue Chen 2
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-10-27 , DOI: 10.1002/anie.202313186
Sen Zhang 1 , Songming Zhang 2 , Yunlong Fan 1 , Xuhai Zhang 1 , Jing Chen 1 , Chaofan Jin 1 , Sisi Chen 2 , Liang Wang 2 , Quan Zhang 1 , Yue Chen 2
Affiliation
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Total synthesis of the proposed structure of neaumycin B was achieved in 22 steps (longest linear sequence) through acid-mediated spiroketalization and a combination of efficient C−C bond forming reactions, including Krische iridium-catalyzed crotylation, Marshall palladium-catalyzed propargylation, Fürstner nickel-catalyzed regio- and enantioselective vicinal monoprotected diol formation, Brown crotylation and asymmetric halide-aldehyde cycloaddition.
中文翻译:
新霉素 B 拟定结构的全合成
通过酸介导的螺缩酮化和有效的 C−C 键形成反应的组合,包括 Krische 铱催化的巴豆酰化、Marshall 钯催化的炔丙基化、Fürstner 等,共 22 个步骤(最长的线性序列)实现了新霉素 B 的拟议结构的全合成。镍催化的区域选择性和对映选择性邻位单保护二醇形成、布朗巴豆酰化和不对称卤化物-醛环加成。
更新日期:2023-10-27
中文翻译:
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新霉素 B 拟定结构的全合成
通过酸介导的螺缩酮化和有效的 C−C 键形成反应的组合,包括 Krische 铱催化的巴豆酰化、Marshall 钯催化的炔丙基化、Fürstner 等,共 22 个步骤(最长的线性序列)实现了新霉素 B 的拟议结构的全合成。镍催化的区域选择性和对映选择性邻位单保护二醇形成、布朗巴豆酰化和不对称卤化物-醛环加成。