急性呼吸道感染儿童人副流感病毒血清型的流行病学及临床严重程度,Virology Journal

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急性呼吸道感染儿童人副流感病毒血清型的流行病学及临床严重程度
Virology Journal ( IF 4.0 ) Pub Date : 2023-10-26 , DOI: 10.1186/s12985-023-02214-9
Le Wang ₁ , Sukun Lu ₁ , Yinghui Guo ₁ , Jianhua Liu ₁ , Peng Wu ₁ , Shuo Yang ₁

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急性呼吸道感染（ARI）对人类健康和生存构成威胁，导致许多儿科住院。然而，人类副流感病毒（PIV）是儿童中最流行的呼吸道病毒之一，其流行病学和临床严重性特征尚不清楚。为了明确PIV感染的流行病学特征，2019年，使用多重聚合酶链反应（PCR）对住院的ARI儿童进行了PIV和其他10种常见呼吸道病原体的筛查。使用逆转录-PCR 对随机选择的 PIV 阳性样本进行亚型分型。对 PIV 亚型之间的人口统计学、流行病学、临床表现、诊断和结果进行了比较。PIV年检出率为14.9%，高峰期为4月至9月。与其他年龄组相比，一岁以下儿童的 PIV 感染率最高（45.5%）。在121个测序样本中，PIV-3、PIV-1和PIV-2阳性率分别为58.7%、36.4%和4.9%，未检测到PIV-4。严重感染与先前存在的基础疾病和合并感染有关，但与 PIV 血清型无关。排除合并感染病例后，我们发现PIV-2感染与上呼吸道感染有关，而PIV-1和PIV-3主要引起下呼吸道感染。除了发热患者的比例外，三种亚型在临床症状、严重程度和转归方面没有显着差异。其中，PIV 是导致住院儿童急性呼吸道感染的主要病原体。对有基础疾病和合并感染的患儿应给予适当关注，防止重症PIV感染病情加重。

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Epidemiology and clinical severity of the serotypes of human parainfluenza virus in children with acute respiratory infection

Acute respiratory infections (ARI) are a threat to human health and survival, resulting in many paediatric hospitalisations. However, the epidemiological and clinical severity characteristics of the human parainfluenza virus (PIV), one of the most prevalent respiratory viruses, are not well understood in children. To identify the epidemiological features of PIV infection, in 2019, hospitalised children with ARI were screened using multiplex polymerase chain reaction (PCR) for PIV and 10 other common respiratory pathogens. Subtyping of randomly selected PIV-positive samples was performed using reverse transcription-PCR. Demographics, epidemiology, clinical manifestations, diagnosis, and outcomes were compared between PIV subtypes. The annual detection rate for PIV was 14.9%, with a peak from April to September. Children under one year of age had the highest rate of PIV infection (45.5%) compared to other age groups. Of the 121 sequenced samples, 58.7%, 36.4% and 4.9% were positive for PIV-3, PIV-1 and PIV-2, respectively, and no PIV-4 was detected. Severe infections were associated with pre-existing underlying diseases and co-infections, but not with PIV serotype. After excluding cases of co-infection, we found that PIV-2 infection was associated with upper respiratory tract infections, whereas PIV-1 and PIV-3 mainly caused lower respiratory tract infections. Apart from the proportion of patients with fever, there were no significant differences among the three subtypes in terms of clinical symptoms, severity, and outcome. Here, PIV was the main pathogen causing ARI in hospitalised children. Appropriate attention should be paid to children with underlying diseases and co-infections to prevent the worsening of severe PIV infection.

更新日期：2023-10-26

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