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A multifaceted assessment of strigolactone GR24 and its derivatives: from anticancer and antidiabetic activities to antioxidant capacity and beyond
Frontiers in Molecular Biosciences ( IF 3.9 ) Pub Date : 2023-10-26 , DOI: 10.3389/fmolb.2023.1242935
Agata Pyrzanowska-Banasiak 1 , Tugba Boyunegmez Tumer 2 , Bożena Bukowska 1 , Anita Krokosz 1
Affiliation  

Background: Strigolactones are signaling molecules produced by plants, the main functions are the intracorporeal control of plant development and plant growth. GR24 strigolactone is one of the synthetic strigolactones and due to its universality and easy availability, it is a standard and model compound for research on the properties and role of strigolactones in human health.Purpose: In this research work, the impact of mainly GR24 strigolactone on the human body and the role of this strigol-type lactone in many processes that take place within the human body are reviewed.Study design: The article is a review of publications on the use of GR24 strigolactone in studies from 2010–2023. Publications were searched using PubMed, Elsevier, Frontiers, and Springer databases. The Google Scholar search engine was also used. For the review original research papers and reviews related to the presented topic were selected.Results: The promising properties of GR24 and other strigolactone analogs in anti-cancer therapy are presented. Tumor development is associated with increased angiogenesis. Strigolactones have been shown to inhibit angiogenesis, which may enhance the anticancer effect of these γ-lactones. Furthermore, it has been shown that strigolactones have anti-inflammatory and antioxidant properties. There are also a few reports which show that the strigolactone analog may have antimicrobial and antiviral activity against human pathogens.Conclusion: When all of this is considered, strigolactones are molecules whose versatile action is their undeniable advantage. The development of research on these phytohormones makes it possible to discover their new, unique properties and surprising biological activities in relation to many mammalian cells.

中文翻译:

对独脚金内酯 GR24 及其衍生物的多方面评估:从抗癌和抗糖尿病活性到抗氧化能力等

背景:独脚金内酯是植物产生的信号分子,主要功能是体内控制植物发育和植物生长。GR24独脚金内酯是合成独脚金内酯之一,由于其通用性和易得性,它是研究独脚金内酯的性质和对人类健康的作用的标准和模型化合物。 目的:在本研究工作中,主要研究GR24独脚金内酯的影响综述了 GR24 独脚金内酯对人体的影响,以及这种独脚金醇型内酯在人体内发生的许多过程中的作用。研究设计:本文是对 2010 年至 2023 年研究中使用 GR24 独脚金内酯的出版物的回顾。使用 PubMed、Elsevier、Frontiers 和 Springer 数据库检索出版物。还使用了谷歌学术搜索引擎。为了进行综述,选择了与所提出的主题相关的原始研究论文和评论。结果:展示了 GR24 和其他独脚金内酯类似物在抗癌治疗中的有前景的特性。肿瘤的发展与血管生成的增加有关。独脚金内酯已被证明可以抑制血管生成,这可能会增强这些 γ-内酯的抗癌作用。此外,研究表明独脚金内酯具有抗炎和抗氧化特性。还有一些报道表明,独脚金内酯类似物可能对人类病原体具有抗菌和抗病毒活性。 结论:当考虑到所有这些因素时,独脚金内酯是一种分子,其多功能作用是其不可否认的优势。对这些植物激素研究的发展使得发现它们与许多哺乳动物细胞相关的新的、独特的性质和令人惊讶的生物活性成为可能。
更新日期:2023-10-26
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