<br>内源性大麻素 N-花生四烯酰多巴胺对慢性睡眠中断引起的痛觉过敏至关重要,Nature Communications

当前位置： X-MOL 学术 › Nat. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

内源性大麻素 N-花生四烯酰多巴胺对慢性睡眠中断引起的痛觉过敏至关重要
Nature Communications ( IF 14.7 ) Pub Date : 2023-10-25 , DOI: 10.1038/s41467-023-42283-6
Weihua Ding ₁ , Liuyue Yang ₁ , Eleanor Shi ₁ , Bowon Kim ₁ , Sarah Low ₁ , Kun Hu ₂ , Lei Gao ₁ , Ping Chen ₃ , Wei Ding ₃ , David Borsook ₄ , Andrew Luo ₅ , Jee Hyun Choi ₆ , Changning Wang ₇ , Oluwaseun Akeju ₁ , Jun Yang ₇ , Chongzhao Ran ₇ , Kristin L Schreiber ₈ , Jianren Mao ₁ , Qian Chen _{9,

10} , Guoping Feng ₉ , Shiqian Shen ₁

Affiliation

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Pathology, Tuft University School of Medicine, Boston, MA, USA.
College of Science and Mathematics, University of Massachusetts Boston, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Summer Intern Program of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, currently at Brandeis University, Boston, MA, USA.
Center for Neuroscience, Korea Institute of Science and Technology, Seoul, South Korea.
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

慢性疼痛非常普遍，并与包括睡眠障碍在内的多种合并症有关。流行病学和临床证据表明，慢性睡眠中断（CSD）导致疼痛敏感性增加，称为 CSD 诱发的痛觉过敏。然而，潜在机制尚不清楚。丘脑网状核（TRN）在感觉处理、注意力/唤醒和睡眠纺锤体生成方面具有独特的综合功能。我们报道，TRN 通过投射到丘脑腹后区域，在 CSD 诱导的小鼠痛觉过敏中发挥重要作用。代谢组学显示，CSD 后 TRN 中 N-花生四烯酰多巴胺（NADA）的水平降低，这是一种内源性大麻素。使用最近开发的具有时空分辨率的 CB1 受体（大麻素受体 1）活性传感器，发现 TRN 中的 CB1 受体活性在 CSD 后降低。此外，对 TRN 的局部 NADA 给药减轻了 CSD 诱导的痛觉过敏。综上所述，这些结果表明 TRN NADA 信号转导对 CSD 诱导的痛觉过敏至关重要。

"点击查看英文标题和摘要"

更新日期：2023-10-25

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南