Off-label metreleptin treatment resulted in cognitive, emotional and behavioral improvements of patients with anorexia nervosa, who presented with hypoleptinemia. We now report a case study of a 16-year-old female patient with atypical anorexia nervosa who was treated off-label with metreleptin for 11 days. She had lost 21 kg over 6 months. Her body mass index at referral for inpatient treatment was 20 kg/m², her serum leptin level was just within the normal range (2.4 ng/ml). Dosing resulted in prominent improvements of mood and weight phobia entailing a comparatively brief inpatient treatment. The observed improvements are similar to those observed in patients with AN, suggesting overlapping mechanisms with respect to clinical effects induced by elevations of absolute or relative hypoleptinemia. Randomized controlled trials are warranted for both eating disorders.

超说明书美曲普汀治疗导致表现为低瘦素血症的神经性厌食症患者的认知、情绪和行为改善。我们现在报告了一名 16 岁非典型神经性厌食症女性患者的案例研究，她接受了 11 天的美曲普汀超说明书治疗。她在 6 个月内减轻了 21 公斤。她转诊住院治疗时的体重指数为 20 kg/m²，血清瘦素水平在正常范围内 （2.4 ng/ml）。给药导致情绪和体重恐惧症的显着改善，需要相对短暂的住院治疗。观察到的改善与 AN 患者中观察到的相似，表明绝对或相对低瘦素血症升高诱导的临床效应存在重叠机制。两种饮食失调都需要随机对照试验。