Off-label metreleptin treatment resulted in cognitive, emotional and behavioral improvements of patients with anorexia nervosa, who presented with hypoleptinemia. We now report a case study of a 16-year-old female patient with atypical anorexia nervosa who was treated off-label with metreleptin for 11 days. She had lost 21 kg over 6 months. Her body mass index at referral for inpatient treatment was 20 kg/m², her serum leptin level was just within the normal range (2.4 ng/ml). Dosing resulted in prominent improvements of mood and weight phobia entailing a comparatively brief inpatient treatment. The observed improvements are similar to those observed in patients with AN, suggesting overlapping mechanisms with respect to clinical effects induced by elevations of absolute or relative hypoleptinemia. Randomized controlled trials are warranted for both eating disorders.

标签外美曲普汀治疗可改善患有低瘦素血症的神经性厌食症患者的认知、情绪和行为。我们现在报告一名 16 岁女性非典型神经性厌食症患者的病例研究，该患者接受美曲普汀超说明书治疗 11 天。她在 6 个月内减掉了 21 公斤。转诊住院治疗时她的体重指数为20 kg/m ² ，血清瘦素水平刚好在正常范围内（2.4 ng/ml）。给药导致情绪和体重恐惧症显着改善，需要相对短暂的住院治疗。观察到的改善与 AN 患者中观察到的改善相似，表明绝对或相对低瘦素血症升高引起的临床效果存在重叠机制。对于这两种饮食失调症都需要进行随机对照试验。