多层水凝胶微立方体：模板颗粒形态对立方水凝胶性能的影响,Macromolecular Materials and Engineering

当前位置： X-MOL 学术 › Macromol. Mater. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

多层水凝胶微立方体：模板颗粒形态对立方水凝胶性能的影响
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2023-10-24 , DOI: 10.1002/mame.202300284
Daniel Inman ₁ , Veronika Kozlovskaya ₁ , Pavel Nikishau ₁ , Sarah Nealy ₁ , Maksim Dolmat ₁ , Jonghwa Oh ₂ , Claudiu T. Lungu ₃ , Lynzi Hunter ₁ , Eugenia Kharlampieva _{1,

3}

Affiliation

非球形刺激响应聚合物颗粒在治疗递送中表现出至关重要的作用。在此，通过在以多孔无机微粒为模板的PMAA/聚( N-乙烯基吡咯烷酮)氢键多层内交联PMAA层来合成pH响应性聚(甲基丙烯酸)(PMAA)立方水凝胶微粒。本研究研究了模板孔隙率和表面形态对 PMAA 多层水凝胶微立方体性能的影响。研究发现，水凝胶结构取决于模板的煅烧时间和温度。pH 触发的 PMAA 水凝胶立方体膨胀取决于水凝胶的内部结构，无论是空心胶囊状还是非空心连续水凝胶。通过高效液相色谱 (HPLC) 分析了微立方体内阿霉素 (DOX) 药物的负载效率，并显示了药物摄取对模板孔隙率控制的网络结构和形态的依赖性。将模板煅烧温度从低温度 (300 °C) 改变到高温度 (1000 °C) 会导致水凝胶立方体对 DOX 的封装增加 2.5 倍。还使用 zeta 电位测量研究了水凝胶表面电荷对 DOX 负载和释放的影响。这项工作深入了解了立方体水凝胶的结构组成、网络形态和 pH 诱导的膨胀的影响，并可能促进用于靶向抗癌药物递送的刺激响应载体的开发。

"点击查看英文标题和摘要"

Multilayer Hydrogel Microcubes: Effects of Templating Particle Morphology on Cubic Hydrogel Properties

Non-spherical stimuli-responsive polymeric particles have shown critical importance in therapeutic delivery. Herein, pH-responsive poly(methacrylic acid) (PMAA) cubic hydrogel microparticles are synthesized by crosslinking PMAA layers within PMAA/poly(N-vinylpyrrolidone) hydrogen-bonded multilayers templated on porous inorganic microparticles. This study investigates the effects of template porosity and surface morphology on the PMAA multilayer hydrogel microcube properties. It is found that the hydrogel structure depends on the template's calcination time and temperature. The pH-triggered PMAA hydrogel cube swelling depends on the hydrogel's internal architecture, either hollow capsule-like or non-hollow continuous hydrogels. The loading efficiency of the doxorubicin (DOX) drug inside the microcubes is analyzed by high-performance liquid chromatography (HPLC), and shows the dependenceof the drug uptake on the network structure and morphology controlled by the template porosity. Varying the template calcination from low (300 °C) to high (1000 °C) temperature results in a 2.5-fold greater DOX encapsulation by the hydrogel cubes. The effects of hydrogel surface charge on the DOX loading and release are also studied using zeta-potential measurements. This work provides insight into the effect of structural composition, network morphology, and pH-induced swelling of the cubical hydrogels and may advance the development of stimuli-responsive vehicles for targeted anticancer drug delivery.

更新日期：2023-10-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南