Ethers are among the most important chemicals in organic synthesis, the pharmaceutical industry, agrochemical production, and material science. C–O bond formation via substitution is one of the most widely used strategies for ether formation. However, known methods usually employ transition-metal and bases to facilitate the process. In this work, we describe the base- and transition-metal-free ether formation via alcohol and phenol-participated substitution. The protocol allows access to a large number of ethers with enyne functional moieties, and features mild reaction conditions, high efficiency, and good regio- and stereoselectivities. The reaction could be readily scaled up, and the products could be used in a range of further transformations.

中文翻译：

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通过醇参与的烯烃烯丙基取代合成过渡金属和无碱醚


醚是有机合成、制药工业、农用化学品生产和材料科学中最重要的化学品之一。通过取代形成 C-O 键是以太形成的最广泛使用的策略之一。然而，已知的方法通常使用过渡金属和碱来促进该过程。在这项工作中，我们描述了通过醇和苯酚参与的取代形成不含碱金属和过渡金属的醚。该方案允许使用大量具有炔官能团的醚，并具有温和的反应条件、高效率以及良好的区域选择性和立体选择性。该反应可以很容易地扩大规模，并且产物可用于一系列进一步的转化。