如何交联明胶：戊二醛和甘油醛对水凝胶性能的影响,ACS Applied Polymer Materials

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如何交联明胶：戊二醛和甘油醛对水凝胶性能的影响
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2023-10-23 , DOI: 10.1021/acsapm.3c01676
Giulia Mugnaini ₁ , Rita Gelli ₁ , Leonardo Mori ₁ , Massimo Bonini ₁

Affiliation

明胶基水凝胶由于其生物相容性、多功能性和可用性而被广泛应用于食品、药品、医疗和化妆品等多个领域。然而，明胶的使用因其在生理温度下热稳定性较差而受到阻碍，并且通常需要进行交联处理以提高其溶解稳定性。戊二醛是最常用的交联剂，但其在生物医学领域的使用引起了一些毒性问题。甘油醛被认为是一种更具生物相容性的替代品，但反应条件及其对水凝胶性能的影响仍不清楚。我们通过改变交联剂浓度和溶剂组成探索了使用戊二醛和甘油醛的不同实验条件。我们表征了水凝胶的反应胺量、膨胀和溶解行为。还研究了形态和纳米级结构，以及压缩时水凝胶的变形。最终研究了模型药物通过水凝胶基质的释放。我们证明，通过改变交联剂的类型和用量，我们可以调整明胶水凝胶的交联程度、溶解行为、微米和纳米结构以及机械性能，强调了替代潜在有毒物质的最合适的实验条件交联剂。

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How to Cross-Link Gelatin: The Effect of Glutaraldehyde and Glyceraldehyde on the Hydrogel Properties

Gelatin-based hydrogels are exploited in a variety of fields, including food, pharmaceuticals, medical, and cosmetics, due to their biocompatibility, versatility, and availability. Gelatin’s use is, although, hampered by its poor thermal stability at physiological temperature, and a cross-linking treatment is often necessary to improve its stability against dissolution. Glutaraldehyde is the most used cross-linking agent, but its use in the biomedical field has raised some toxicity issues. Glyceraldehyde was proposed as a more biocompatible alternative, but the reaction conditions and its effect on the hydrogel properties are still unclear. We explored different experimental conditions using glutaraldehyde and glyceraldehyde by varying cross-linker concentration and solvent composition. We characterized the amount of reacted amines, swelling, and dissolution behavior of the hydrogels. The morphology and the nanoscale structure were also investigated, as well as hydrogel deformation upon compression. The release of a model drug through the hydrogel matrix was finally investigated. We demonstrated that by changing the cross-linker type and amount, we can tune the cross-linking extent, the dissolution behavior, the micro- and nanostructure, and the mechanical properties of gelatin hydrogels, highlighting the most appropriate experimental conditions to substitute potentially toxic cross-linking agents.

更新日期：2023-10-23

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