In this work, we have reported continuous flow synthesis of 1-ethyl-3-methylimidazolium ethyl sulfate ionic liquid in a PTFE micro-capillary. A Y-shaped microfluidic junction is used to mix the incoming reactants. Effects of independent parameters like velocity, reaction temperature, and micro-capillary diameter on product yield, rate of production, and space–time yield are reported. Yield is seen to increase monotonically as reaction temperature is increased, while it reduces with an increase in diameter of the micro-capillary. A maxima in yield is observed as flow velocity is increased. A space–time yield of 1258.4 g/min.L is obtained at a reaction temperature of 80 ⁰C using a 300 µm micro-capillary. A two-dimensional computational fluid dynamics (CFD) model of the reacting system has been developed to confirm and explain the observed experimental trends. The simulations were able to qualitatively predict the experimental trends. The simulations also investigated the effect of shapes of different obstacles placed in the flow path.

在这项工作中，我们报道了在 PTFE 微毛细管中连续流动合成 1-乙基-3-甲基咪唑鎓乙基硫酸盐离子液体。 Y 形微流体连接用于混合进入的反应物。报道了速度、反应温度和微毛细管直径等独立参数对产物收率、生产率和时空收率的影响。随着反应温度的增加，产率单调增加，而随着微毛细管直径的增加，产率减少。当流速增加时观察到产量的最大值。使用 300 µm 微毛细管，在 80 ⁰ C的反应温度下获得 1258.4 g/min.L 的时空产率。已经开发了反应系统的二维计算流体动力学（CFD）模型来确认和解释观察到的实验趋势。模拟能够定性预测实验趋势。模拟还研究了放置在流动路径中的不同障碍物形状的影响。