Nanoparticle‐Assisted Affinity NMR Spectroscopy: High Sensitivity Detection and Identification of Organic Molecules,Chemistry - A European Journal

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Nanoparticle‐Assisted Affinity NMR Spectroscopy: High Sensitivity Detection and Identification of Organic Molecules
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2016-10-10 , DOI: 10.1002/chem.201603578
Marta Diez-Castellnou ₁ , Marie-Virginie Salvia _{1,

2} , Sara Springhetti ₁ , Federico Rastrelli ₁ , Fabrizio Mancin ₁

Affiliation

A simple and effective method for high‐sensitivity NMR detection of selected compounds is reported. The method combines 1D NMR diffusion filter experiments and small monolayer‐protected nanoparticles as high‐affinity receptors. Once bound to the nanoparticles, the diffusion coefficient of the analyte decreases in such way that spectral editing based on diffusion filters can separate its signals from those of other mixture components. Using nanoparticles functionalized with Zn²⁺‐triazacyclonane complexes, detection and identification of phosphorylated organic molecules can be achieved. Diphenyl phosphate can be detected at 25 micromolar concentration with good selectivity. The selectivity toward organic carboxylates is enhanced at pD=3.75. In these conditions, commercial tablets containing betamethasone phosphate and a large excess of benzoate could be successfully analyzed.

中文翻译：

纳米粒子亲和NMR光谱：有机分子的高灵敏度检测和鉴定

报告了一种简单有效的方法，用于高灵敏度NMR检测所选化合物。该方法结合了1D NMR扩散过滤器实验和作为高亲和力受体的小单层保护纳米颗粒。一旦与纳米颗粒结合，分析物的扩散系数就会以这种方式降低，即基于扩散滤镜的光谱编辑可以将其信号与其他混合物成分的信号分开。使用被Zn ²⁺官能化的纳米颗粒triazacyclonane配合物，可以实现磷酸化有机分子的检测和鉴定。可以在25微摩尔浓度下以良好的选择性检测到磷酸二苯酯。在pD ＝ 3.75时，提高了对有机羧酸盐的选择性。在这些条件下，可以成功分析含有磷酸倍他米松和大量苯甲酸酯的市售片剂。

更新日期：2016-10-10

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