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Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-10-20 , DOI: 10.1021/acs.jafc.3c02337 Fanghua Guo 1 , Hua Xiong 1 , Rong Tsao 2 , Fereidoon Shahidi 3 , Xushen Wen 1 , Jiahua Liu , Li Jiang 4 , Yong Sun 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-10-20 , DOI: 10.1021/acs.jafc.3c02337 Fanghua Guo 1 , Hua Xiong 1 , Rong Tsao 2 , Fereidoon Shahidi 3 , Xushen Wen 1 , Jiahua Liu , Li Jiang 4 , Yong Sun 1
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Green pea hull is a processing byproduct of green pea and rich in polyphenols. Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease characterized by accumulation of lipids in the liver for which there are no effective treatment strategies. Here, a mouse model of NAFLD induced by a DSS+high-fat diet (HFD) was established to investigate the effect of green pea hull polyphenol extract (EGPH). The results show that EGPH relief of NAFLD was a combined effect, including reducing hepatic fat accumulation, improving antioxidant activity and blood lipid metabolism, and maintaining glucose homeostasis. Increased intestinal permeability aggravated NAFLD. Combined metabolomics and transcriptomic analysis showed that vitamin B6 is the key target substance for EGPH to alleviate NAFLD, and it may be the intestinal flora metabolite. After EGPH intervention, the level of vitamin B6 in mice was significantly increased, and more than 60% in the blood enters the liver, which activated or inhibited PPAR and TLR4/NF-κB signaling pathways to relieve NAFLD. Our research could be a win–win for expanding the use of green pea hull and the search for NAFLD prophylactic drugs.
中文翻译：
绿豌豆 (Pisum sativum L.) 壳多酚提取物通过 VB6/TLR4/NF-κB 和 PPAR 途径减轻 NAFLD
青豌豆壳是青豌豆的加工副产品，富含多酚。非酒精性脂肪性肝病（NAFLD）是一种慢性代谢性疾病，其特征是肝脏中脂质蓄积，目前尚无有效的治疗策略。本研究建立了DSS+高脂饮食（HFD）诱导的NAFLD小鼠模型，以研究青豌豆壳多酚提取物（EGPH）的作用。结果表明，EGPH缓解NAFLD是一种综合效应，包括减少肝脏脂肪积累、改善抗氧化活性和血脂代谢、维持葡萄糖稳态。肠道通透性增加加重NAFLD。结合代谢组学和转录组学分析表明，维生素B6是EGPH缓解NAFLD的关键靶标物质，可能是肠道菌群代谢产物。 EGPH干预后，小鼠体内维生素B6水平显着升高，血液中60%以上进入肝脏，激活或抑制PPAR和TLR4/NF-κB信号通路，从而缓解NAFLD。我们的研究对于扩大青豌豆壳的使用和寻找 NAFLD 预防药物来说可能是双赢的。
更新日期：2023-10-20
中文翻译：
绿豌豆 (Pisum sativum L.) 壳多酚提取物通过 VB6/TLR4/NF-κB 和 PPAR 途径减轻 NAFLD
青豌豆壳是青豌豆的加工副产品，富含多酚。非酒精性脂肪性肝病（NAFLD）是一种慢性代谢性疾病，其特征是肝脏中脂质蓄积，目前尚无有效的治疗策略。本研究建立了DSS+高脂饮食（HFD）诱导的NAFLD小鼠模型，以研究青豌豆壳多酚提取物（EGPH）的作用。结果表明，EGPH缓解NAFLD是一种综合效应，包括减少肝脏脂肪积累、改善抗氧化活性和血脂代谢、维持葡萄糖稳态。肠道通透性增加加重NAFLD。结合代谢组学和转录组学分析表明，维生素B6是EGPH缓解NAFLD的关键靶标物质，可能是肠道菌群代谢产物。 EGPH干预后，小鼠体内维生素B6水平显着升高，血液中60%以上进入肝脏，激活或抑制PPAR和TLR4/NF-κB信号通路，从而缓解NAFLD。我们的研究对于扩大青豌豆壳的使用和寻找 NAFLD 预防药物来说可能是双赢的。
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