Atractylodes lancea Rhizome Polysaccharide Alleviates Immunosuppression and Intestinal Mucosal Injury in Mice Treated with Cyclophosphamide,Journal of Agricultural and Food Chemistry

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Atractylodes lancea Rhizome Polysaccharide Alleviates Immunosuppression and Intestinal Mucosal Injury in Mice Treated with Cyclophosphamide
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-10-20 , DOI: 10.1021/acs.jafc.3c05173
Dongpeng Wang ₁ , Yan Dong ₁ , Ying Xie ₁ , Yangxin Xiao ₁ , Chang Ke ₁ , Kun Shi ₁ , Zhongshi Zhou _{1,

2} , Jiyuan Tu _{1,

2} , Linghang Qu _{1,

2} , Yanju Liu _{1,

2}

Affiliation

Plant-derived polysaccharides, such as Atractylodes lancea rhizome polysaccharide (ALP), are good immune regulators. However, the immune regulatory mechanism of the ALP is unknown. This study aimed to evaluate the effects of ALP on the intestinal mucosal barrier and intestinal mucosal immunity of immunosuppressed mice. We also compared the activity of raw Atractylodes lancea rhizome polysaccharide (SALP) with wheat bran processed bran-fried Atractylodes lancea rhizome polysaccharide (FALP; both at 1.2 g/kg/d for mice). Our results showed that ALP effectively increased the immune organ index and blood cell count, stimulated the secretion of cytokines, and promoted the expression of occludin and zonula occludens-1 (ZO-1). ALP also promoted the expression of T cells and the secretion of sIgA. Furthermore, ALP alleviated the gut microbiota disorder in Cy-treated mice and increased the relative abundances of Lactobacillus and Faecalibaculum. ALP reversed the decrease in the level of SCFAs and promoted the expression of G protein-coupled receptor 43 (GPR43). To our knowledge, this study was the first to explore how the ALP protects the intestinal mucosal barrier and enhances intestinal mucosal immunity by alleviating the gut microbiota imbalance and metabolic disorders of SCFAs. FALP was more therapeutic than SALP, suggesting that FALP could be developed as a promising functional food component.

中文翻译：

白术多糖减轻环磷酰胺治疗小鼠的免疫抑制和肠粘膜损伤

植物源性多糖，例如白术多糖（ALP），是良好的免疫调节剂。然而，ALP的免疫调节机制尚不清楚。本研究旨在评价ALP对免疫抑制小鼠肠粘膜屏障和肠粘膜免疫的影响。我们还比较了生苍术多糖（SALP）和麦麸加工的麸炒苍术多糖（FALP；小鼠剂量均为 1.2 g/kg/d）的活性。我们的结果表明，ALP 有效增加免疫器官指数和血细胞计数，刺激细胞因子的分泌，并促进 occludin 和 zonula occlusionns-1 (ZO-1) 的表达。ALP还促进T细胞的表达和sIgA的分泌。此外，ALP 缓解了 Cy 治疗小鼠的肠道微生物群紊乱，并增加了乳酸杆菌和Faecalibaculum的相对丰度。ALP 逆转了 SCFA 水平的下降，并促进 G 蛋白偶联受体 43 (GPR43) 的表达。据我们所知，本研究首次探讨ALP如何通过缓解肠道菌群失衡和SCFAs代谢紊乱来保护肠粘膜屏障并增强肠粘膜免疫。FALP 比 SALP 更具治疗作用，表明 FALP 可以开发为一种有前途的功能性食品成分。

更新日期：2023-10-20

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