Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis,Helvetica Chimica Acta

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Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis
Helvetica Chimica Acta ( IF 1.5 ) Pub Date : 2023-10-18 , DOI: 10.1002/hlca.202300143
Nicholas Isley ₁ , Fabrice Gallou ₁

Affiliation

A scalable and environmentally benign protocol for a Suzuki–Miyaura cross-coupling in water using vitamin E derived surfactant TPGS-750-M is reported. The protocol is the most simple and standard for such transformations under micellar catalysis that has been amply utilized within our own research and development portfolio over the last decade. The impact of the synthetic procedure is reenforced by green Process Mass Intensity and Total Carbon Release metrics.

中文翻译：

利用胶束催化通过 Suzuki-Miyaura 交叉偶联公斤级合成 4-Chloro-6-(6-methoxypyridin-3-yl)pyrimidine

据报道，使用维生素 E 衍生的表面活性剂 TPGS-750-M 在水中进行铃木-宫浦交叉偶联的可扩展且环境友好的方案。该方案是胶束催化下此类转化的最简单和标准的方案，在过去十年中已在我们自己的研发组合中得到充分利用。绿色工艺质量强度和总碳释放指标强化了合成过程的影响。

更新日期：2023-10-18

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