Straightforward method for the synthesis of 2H-furo[3,2-b]pyran-2-one derivatives starting from allomaltol,Journal of Heterocyclic Chemistry

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Straightforward method for the synthesis of 2H-furo[3,2-b]pyran-2-one derivatives starting from allomaltol
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2023-10-18 , DOI: 10.1002/jhet.4744
Andrey N. Komogortsev ₁ , Boris V. Lichitsky ₁ , Constantine V. Milyutin ₁ , Valeriya G. Melekhina ₁

Affiliation

We developed a facile approach for the preparation of a rare 2H-furo[3,2-b]pyran-2-one system. The suggested method is based on a two-step process using unsubstituted allomaltol as a starting compound. The key stage of the considered route is a condensation of 2-(2-aryl-2-oxoethyl)-3-hydroxy-6-methyl-4H-pyran-4-ones with 1,1-carbonyldiimidazole. The advantages of the presented method are commercially available starting materials and convenient experimental procedures including simple isolation of the target compounds. The structure of one of the 2H-furo[3,2-b]pyran-2-ones was confirmed by x-ray diffraction.

中文翻译：

以异麦芽酚为原料合成 2H-呋喃并[3,2-b]吡喃-2-酮衍生物的简单方法

我们开发了一种简便的方法来制备罕见的 2 H -furo[3,2- b ]pyran-2-one 系统。建议的方法基于使用未取代的别麦芽酚作为起始化合物的两步过程。所考虑路线的关键阶段是2-(2-芳基-2-氧代乙基)-3-羟基-6-甲基-4H-吡喃-4-酮与1,1-羰基二咪唑的缩合。该方法的优点是可商购起始材料和方便的实验程序，包括目标化合物的简单分离。通过X射线衍射证实了2 H-呋喃[3,2- b ]吡喃-2-酮之一的结构。

更新日期：2023-10-18

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