Megasynthases are responsible for producing primary metabolites and complex natural products. The final products are built in a stepwise process in which small acyl carrier proteins (ACPs) play a central role as they shuttle the growing intermediates between the different catalytic domains. This Review provides an overview of the current understanding and proposes a mechanism for the programming of the ACP movement in megasynthases.

中文翻译：

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酰基载体蛋白 (ACP) 如何指导脂肪酸和聚酮化合物的生物合成


大合成酶负责产生初级代谢物和复杂的天然产物。最终产品是通过逐步过程构建的，其中小酰基载体蛋白 (ACP) 在不同催化域之间穿梭生长的中间体时发挥着核心作用。本综述概述了当前的理解，并提出了一种在大型合成酶中对 ACP 运动进行编程的机制。