Perivascular spaces (PVS), fluid-filled compartments surrounding brain vasculature, are an essential component of the glymphatic system responsible for transport of waste and nutrients. Glymphatic system impairment may underlie cognitive deficits in Parkinson’s disease (PD). Studies have focused on the role of basal ganglia PVS with cognition in PD, but the role of white matter PVS is unknown. This study examined the relationship of white matter and basal ganglia PVS with domain-specific and global cognition in individuals with PD. Fifty individuals with PD underwent 3T T1w magnetic resonance imaging (MRI) to determine PVS volume fraction, defined as PVS volume normalized to total regional volume, within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessment of global cognitive function (Montreal Cognitive Assessment, and global cognitive composite score), and cognitive-specific domains (executive function, memory, visuospatial function, attention, and language). Higher white matter rostral middle frontal PVS was associated with lower scores in both global cognitive and visuospatial function. In the basal ganglia higher PVS was associated with lower scores for memory with a trend towards lower global cognitive composite score. While previous reports have shown that greater amount of PVS in the basal ganglia is associated with decline in global cognition in PD, our findings suggest that increased white matter PVS volume may also underlie changes in cognition.

血管周围空间（PVS）是脑血管系统周围充满液体的隔室，是负责运输废物和营养物质的类淋巴系统的重要组成部分。类淋巴系统损伤可能是帕金森病 (PD) 认知缺陷的基础。研究重点关注基底节PVS在PD中与认知的作用，但白质PVS的作用尚不清楚。本研究探讨了 PD 患者白质和基底神经节 PVS 与特定领域和整体认知的关系。 50 名 PD 患者接受了 3T T1w 磁共振成像 (MRI)，以确定 (i) 半卵圆中心、(ii) 前额白质（内侧眶额、喙中额叶、 (iii) 基底神经节。神经心理学电池包括对整体认知功能的评估（蒙特利尔认知评估和整体认知综合评分）和特定认知领域（执行功能、记忆、视觉空间功能、注意力和语言）。较高的白质头端中额叶 PVS 与较低的整体认知和视觉空间功能得分相关。在基底神经节中，较高的 PVS 与较低的记忆得分相关，并且总体认知综合得分有较低的趋势。虽然之前的报告表明，基底神经节中大量的 PVS 与 PD 整体认知能力下降有关，但我们的研究结果表明，白质 PVS 体积的增加也可能是认知变化的基础。