A cost-effective, scalable, high-yielding, and commercially viable synthesis of 4-bromo-1,2-dimethyl-1H-imidazole (1), an important building block to construct various bioactive molecules has been established. The main feature of this method includes the selection of appropriate starting material 1,2-dimethyl-1H-imidazole in which the existing issue of regioisomer formation is circumvented and the selective debromination is accomplished by using isopropyl magnesium chloride.

中文翻译：

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经济高效且可规模化的 4-溴-1,2-二甲基-1H-咪唑合成：生物活性分子的关键组成部分

4-溴-1,2-二甲基-1H-咪唑 (1) 是构建各种生物活性分子的重要组成部分，已经建立了一种经济有效、可扩展、高产且商业上可行的合成方法。该方法的主要特点包括选择合适的起始原料1,2-二甲基-1H-咪唑，避免了现有的区域异构体形成问题，并通过使用异丙基氯化镁完成选择性脱溴。