Background/aim To examine the relationship between baseline blood flow biomarkers and long-term open-angle glaucoma (OAG) progression. Methods 112 patients with early to moderate OAG (mean age 64.9±11.0 years; 68 female) were evaluated at baseline and every 6 months from 2008 to 2013. Biomarkers of retinal capillary blood flow were assessed by Heidelberg retinal flowmetry. Functional disease progression was monitored via Humphrey visual field examinations, defined as two consecutive visits with a mean deviation decrease ≥2 decibels and/or Advanced Glaucoma Intervention Study score increase ≥2 compared with baseline. Structural progression was monitored with optical coherence tomography and Heidelberg retinal tomograph, defined as two consecutive visits with retinal nerve fibre layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared with baseline. Mixed-model analysis of covariance was used to test for significant change from baseline to 5-year follow-up. Times to functional and structural progression were analysed using Cox proportional hazards models. Results Lower HRF retinal capillary blood flow in the superior retina was significantly associated with structural progression (p=0.0009). Conclusion In our OAG sample, baseline lower retinal capillary perfusion in the superior retina was predictive of structural progression after 5 years. Trial registration number [NCT01145911][1]. Data are available upon reasonable request. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01145911&atom=%2Fbjophthalmol%2F108%2F7%2F946.atom

中文翻译：

---

眼血流生物标志物可以预测青光眼的长期进展


背景/目的 检查基线血流生物标志物与长期开角型青光眼 (OAG) 进展之间的关系。方法 2008 年至 2013 年期间，对 112 名早中度 OAG 患者（平均年龄 64.9±11.0 岁；68 名女性）进行基线评估和每 6 个月一次评估。通过海德堡视网膜血流计评估视网膜毛细血管血流生物标志物。通过 Humphrey 视野检查监测功能性疾病进展，定义为与基线相比，连续两次就诊平均偏差降低 ≥2 分贝和/或高级青光眼干预研究评分增加 ≥2。使用光学相干断层扫描和海德堡视网膜断层扫描监测结构进展，定义为与基线相比，连续两次就诊时视网膜神经纤维层厚度减少≥8%和/或水平或垂直杯/盘比增加≥0.2。使用协方差的混合模型分析来测试从基线到 5 年随访的显着变化。使用 Cox 比例风险模型分析功能和结构进展的时间。结果 上视网膜 HRF 较低的视网膜毛细血管血流量与结构进展显着相关 (p=0.0009)。结论 在我们的 OAG 样本中，上视网膜中基线较低的视网膜毛细血管灌注可预测 5 年后的结构进展。试用注册号[NCT01145911][1]。数据可根据合理要求提供。 [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01145911&atom=%2Fbjophamol%2F108%2F7%2F946.atom