肥胖及相关疾病中的肌间脂肪组织：细胞起源、生物学特性和调节机制,Frontiers in Endocrinology

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肥胖及相关疾病中的肌间脂肪组织：细胞起源、生物学特性和调节机制
Frontiers in Endocrinology ( IF 3.9 ) Pub Date : 2023-10-18 , DOI: 10.3389/fendo.2023.1280853
Ting Zhang _{1,

2,

3} , Jun Li ₄ , Xi Li ₅ , Yanjun Liu _{1,

2}

Affiliation

肌间脂肪组织（IMAT）是散布在肌纤维（肌纤维）或肌肉群之间的独特脂肪库。大量研究表明，IMAT 与肥胖和 2 型糖尿病等代谢性疾病患者的胰岛素抵抗和肌肉功能障碍密切相关。此外，IMAT通过分泌因子加剧肥胖相关的肌肉代谢紊乱。有趣的是，研究人员发现啮齿动物模型中的肌间棕色脂肪细胞通过作用于能量耗散为肥胖治疗提供了新的希望，这激发了研究人员探索IMAT形成的潜在调控机制。然而，IMAT 的分子和细胞特性以及调控过程仍然存在争议。先前的研究表明，肌肉来源的干/祖细胞和其他脂肪组织祖细胞有助于 IMAT 的发展。IMAT 内的脂肪细胞表现出与白色脂肪细胞或解偶联蛋白 1 (UCP1) 阳性棕色脂肪细胞相似的特征。此外，考虑到骨骼肌（包括肌纤维、卫星细胞和常驻间充质祖细胞）的异质性，这些细胞成分之间的相互作用可能积极参与肌间脂肪生成的调节。在此背景下，我们回顾了最近与 IMAT 相关的研究，以深入了解 IMAT 的细胞起源、生物学特性和调节机制。我们的目的是为IMAT的治疗策略以及针对IMAT相关代谢性疾病的新药开发提供新思路。

"点击查看英文标题和摘要"

Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms

Intermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease, such as obesity and type 2 diabetes. Moreover, IMAT aggravates obesity-related muscle metabolism disorders via secretory factors. Interestingly, researchers have discovered that intermuscular brown adipocytes in rodent models provide new hope for obesity treatment by acting on energy dissipation, which inspired researchers to explore the underlying regulation of IMAT formation. However, the molecular and cellular properties and regulatory processes of IMAT remain debated. Previous studies have suggested that muscle-derived stem/progenitor cells and other adipose tissue progenitors contribute to the development of IMAT. Adipocytes within IMAT exhibit features that are similar to either white adipocytes or uncoupling protein 1 (UCP1)-positive brown adipocytes. Additionally, given the heterogeneity of skeletal muscle, which comprises myofibers, satellite cells, and resident mesenchymal progenitors, it is plausible that interplay between these cellular components actively participate in the regulation of intermuscular adipogenesis. In this context, we review recent studies associated with IMAT to offer insights into the cellular origins, biological properties, and regulatory mechanisms of IMAT. Our aim is to provide novel ideas for the therapeutic strategy of IMAT and the development of new drugs targeting IMAT-related metabolic diseases.

更新日期：2023-10-18

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