Dynamic regulation of LINC complex composition and function across tissues and contexts,FEBS Letters

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Dynamic regulation of LINC complex composition and function across tissues and contexts
FEBS Letters ( IF 3.0 ) Pub Date : 2023-10-17 , DOI: 10.1002/1873-3468.14757
Megan C King _{1,

2}

Affiliation

The concept of mechanotransduction to the nucleus through a direct force transmission mechanism has fascinated cell biologists for decades. Central to such a mechanism is the linker of nucleoskeleton and cytoskeleton (LINC) complex, which spans the nuclear envelope to couple the cytoplasmic cytoskeleton to the nuclear lamina. In reality, there is not one LINC complex identity, but instead, a family of protein configurations of varied composition that exert both shared and unique functions. Regulated expression of LINC complex components, splice variants, and mechanoresponsive protein turnover mechanisms together shape the complement of LINC complex forms present in a given cell type. Disrupting specific gene(s) encoding LINC complex components therefore gives rise to a range of organismal defects. Moreover, evidence suggests that the mechanical environment remodels LINC complexes, providing a feedback mechanism by which cellular context influences the integration of the nucleus into the cytoskeleton. In particular, evidence for crosstalk between the nuclear and cytoplasmic intermediate filament networks communicated through the LINC complex represents an emerging theme in this active area of ongoing investigation.

中文翻译：

跨组织和环境的 LINC 复合物组成和功能的动态调节

通过直接力传递机制对细胞核进行机械传导的概念几十年来一直让细胞生物学家着迷。这种机制的核心是核骨架和细胞骨架（LINC）复合物的连接体，它跨越核膜将细胞质细胞骨架与核纤层偶联。事实上，不存在单一的 LINC 复杂特性，而是一系列具有不同组成的蛋白质构型，它们发挥着共享和独特的功能。 LINC 复合体成分、剪接变体和机械响应蛋白周转机制的调节表达共同塑造了给定细胞类型中存在的 LINC 复合体形式的补充。因此，破坏编码 LINC 复合体成分的特定基因会导致一系列有机体缺陷。此外，有证据表明机械环境重塑 LINC 复合物，提供反馈机制，细胞环境通过该机制影响细胞核与细胞骨架的整合。特别是，通过 LINC 复合体通讯的核和细胞质中间丝网络之间的串扰证据代表了这个正在进行的研究活跃领域的一个新兴主题。

更新日期：2023-10-17

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