N6-Methyladenosine mRNA Modification: From Modification Site Selectivity to Neurological Functions,Accounts of Chemical Research

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N6-Methyladenosine mRNA Modification: From Modification Site Selectivity to Neurological Functions
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2023-10-17 , DOI: 10.1021/acs.accounts.3c00440
Zeyu Zhang ₁ , Xiu-Jie Wang _{1,

2}

Affiliation

The development of various chemical methods has enabled scientists to decipher the distribution features and biological functions of RNA modifications in the past decade. In addition to modifying noncoding RNAs such as tRNAs and rRNAs, N⁶-methyladenosine (m⁶A) has been proven to be the most abundant internal chemical modification on mRNAs in eukaryotic cells and is also the most widely studied mRNA modification to date. Extensive studies have repeatedly demonstrated the important functions of m⁶A in various biological conditions, ranging from embryonic organ development to adult organ function and pathogenesis. Unlike DNA methylation which is relatively stable, the reversible m⁶A modification on mRNA is highly dynamic and easily influenced by various internal or external factors, such as cell type, developmental stage, nutrient supply, circadian rhythm, and environmental stresses.

中文翻译：

N6-甲基腺苷 mRNA 修饰：从修饰位点选择性到神经功能

近十年来，各种化学方法的发展使科学家们能够破译RNA修饰的分布特征和生物学功能。除了修饰tRNA和rRNA等非编码RNA外，N ⁶ -甲基腺苷（m ⁶ A）已被证明是真核细胞中mRNA最丰富的内部化学修饰，也是迄今为止研究最广泛的mRNA修饰。广泛的研究反复证明了 m ⁶ A 在各种生物条件下的重要功能，从胚胎器官发育到成人器官功能和发病机制。与相对稳定的DNA甲基化不同，mRNA上的可逆m ⁶ A修饰是高度动态的，很容易受到各种内部或外部因素的影响，例如细胞类型、发育阶段、营养供应、昼夜节律和环境压力。

更新日期：2023-10-17

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