Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma,Angewandte Chemie International Edition

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Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-10-17 , DOI: 10.1002/anie.202312603
Chunrong Yang ₁ , Yujie Li ₂ , Yuchen Yang ₁ , Qiankun Ni ₁ , Zeyu Zhang ₃ , Yi Chai ₄ , Jinghong Li _{1,

2,

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Affiliation

A nanomedicine was designed to modulate the tumor microenvironment (TME) against glioma (GBM). Upon intravenous injection, the nanomedicine penetrated the blood–brain barrier and accumulated within the TME of GBM-bearing mice, which subsequently abolished the negative feedback regulation function of SOCS1 on dendritic cell maturation and T cell proliferation, elicited strong cytotoxic T lymphocyte responses, and inhibited tumor growth.

中文翻译：

合成高密度脂蛋白纳米药物可沉默肿瘤微环境中的 SOCS1 并触发针对神经胶质瘤的抗肿瘤免疫

纳米药物旨在调节肿瘤微环境（TME）对抗神经胶质瘤（GBM）。静脉注射后，纳米药物穿透血脑屏障并在GBM小鼠的TME内积累，随后消除了SOCS1对树突状细胞成熟和T细胞增殖的负反馈调节功能，引发强烈的细胞毒性T淋巴细胞反应，抑制肿瘤生长。

更新日期：2023-10-17

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