MAP kinases may mediate regulation of the cell cycle in rice by E2F2 phosphorylation,FEBS Letters

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MAP kinases may mediate regulation of the cell cycle in rice by E2F2 phosphorylation
FEBS Letters ( IF 3.0 ) Pub Date : 2023-10-16 , DOI: 10.1002/1873-3468.14753
Dhanraj Singh ₁ , Gopal Banerjee ₁ , Neetu Verma ₁ , Alok Krishna Sinha ₁

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E2F is the key transcription factor that determines the proliferative status of cells by regulating the G1/S phase of the cell cycle. In this study, we show that in rice (Oryza sativa), OsE2F2 is a phosphorylation target of MAP kinases. The MAP kinases OsMPK3, OsMPK4, and OsMPK6 interact with and phosphorylate OsE2F2. Next, we determined the serine and threonine residues that could play a role in the phosphorylation of OsE2F2. Subsequently, our study suggests a possible link between MAP kinase-mediated OsE2F2 phosphorylation and its impact on DNA proliferation in the roots of rice seedlings. Finally, we found positive feedback regulation of OsMPK4 by OsE2F2. Therefore, our study hints at the potential impact of MAP kinase signaling on the cell cycle of rice plants.

中文翻译：

MAP 激酶可能通过 E2F2 磷酸化介导水稻细胞周期的调节

E2F是关键转录因子，通过调节细胞周期的G1/S期来决定细胞的增殖状态。在这项研究中，我们证明在水稻 ( Oryza sativa ) 中，OsE2F2 是 MAP 激酶的磷酸化靶标。 MAP 激酶 OsMPK3、OsMPK4 和 OsMPK6 与 OsE2F2 相互作用并磷酸化 OsE2F2。接下来，我们确定了可能在 OsE2F2 磷酸化中发挥作用的丝氨酸和苏氨酸残基。随后，我们的研究表明 MAP 激酶介导的 OsE2F2 磷酸化与其对水稻幼苗根部 DNA 增殖的影响之间可能存在联系。最后，我们发现OsE2F2对OsMPK4的正反馈调节。因此，我们的研究暗示了 MAP 激酶信号对水稻细胞周期的潜在影响。

更新日期：2023-10-16

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