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Unravelling the Secrets of α-Pyrones from Aspergillus Fungi: A Comprehensive Review of Their Natural Sources, Biosynthesis, and Biological Activities
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-10-12 , DOI: 10.1002/cbdv.202301185
Mostafa A Asmaey 1
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-10-12 , DOI: 10.1002/cbdv.202301185
Mostafa A Asmaey 1
Affiliation
|
Aspergillus, one of the most product-rich and genetically robust genera, contains a diverse range of species with potential economic and ecological implications. Chemically, Aspergillus is one of the essential sources of polyketides, alkaloids, diphenyl ethers, diketopiperazines, and other miscellaneous compounds, displaying a variety of pharmacological activities. The α-pyrones are unsaturated six-membered lactones. Although α-pyrone has a small structure, it is responsible for the structural diversity of several natural and synthetic compounds and multiple biological activities. In this review, we have summarized approximately 178 α-pyrone containing metabolites derivatives identified/reported from terrestrial, marine, endophytic, and filamentous Aspergillus species, including their sources, biological properties, and biosynthetic pathways until mid-2023, for the first time. This review is the first to compile and analyze the available data on α-pyrone metabolites from Aspergillus, which could facilitate further research and innovation in this field. Additionally, it offers a valuable source of scaffolds for future bioactive drug development, as some of these metabolites have shown potent antimicrobial, anti-inflammatory, and anticancer effects. Therefore, this review has significant implications for the advancement of natural product chemistry, pharmacology, biotechnology, and medicine.
中文翻译：
揭开曲霉菌中 α-吡喃酮的秘密：对其天然来源、生物合成和生物活性的全面回顾
曲霉属是产品最丰富、遗传力最强的属之一，包含多种具有潜在经济和生态影响的物种。从化学角度来看，曲霉是聚酮化合物、生物碱、二苯醚、二酮哌嗪和其他多种化合物的重要来源之一，具有多种药理活性。α-吡喃酮是不饱和六元内酯。尽管α-吡喃酮结构很小，但它导致了多种天然和合成化合物的结构多样性以及多种生物活性。在这篇综述中，我们首次总结了截至 2023 年中期从陆地、海洋、内生和丝状曲霉属物种中鉴定/报告的约 178 种含有α-吡喃酮的代谢物衍生物，包括它们的来源、生物学特性和生物合成途径。本综述首次对曲霉属α-吡喃酮代谢物的现有数据进行了汇编和分析，这可以促进该领域的进一步研究和创新。此外，它为未来生物活性药物的开发提供了宝贵的支架来源，因为其中一些代谢物已显示出有效的抗菌、抗炎和抗癌作用。因此，这篇综述对天然产物化学、药理学、生物技术和医学的进步具有重要意义。
更新日期：2023-10-12
中文翻译：
揭开曲霉菌中 α-吡喃酮的秘密：对其天然来源、生物合成和生物活性的全面回顾
曲霉属是产品最丰富、遗传力最强的属之一，包含多种具有潜在经济和生态影响的物种。从化学角度来看，曲霉是聚酮化合物、生物碱、二苯醚、二酮哌嗪和其他多种化合物的重要来源之一，具有多种药理活性。α-吡喃酮是不饱和六元内酯。尽管α-吡喃酮结构很小，但它导致了多种天然和合成化合物的结构多样性以及多种生物活性。在这篇综述中，我们首次总结了截至 2023 年中期从陆地、海洋、内生和丝状曲霉属物种中鉴定/报告的约 178 种含有α-吡喃酮的代谢物衍生物，包括它们的来源、生物学特性和生物合成途径。本综述首次对曲霉属α-吡喃酮代谢物的现有数据进行了汇编和分析，这可以促进该领域的进一步研究和创新。此外，它为未来生物活性药物的开发提供了宝贵的支架来源，因为其中一些代谢物已显示出有效的抗菌、抗炎和抗癌作用。因此，这篇综述对天然产物化学、药理学、生物技术和医学的进步具有重要意义。
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