Photothermal conversion efficiency (PCE) plays a crucial role in tumor photothermal therapy (PTT). In this work, we developed a MoS-based antitumor agent with enhanced photothermal conversion efficiency by size/morphology tailoring and IR820 loading for combinational photothermal/photodynamic therapy (PTT/PDT) of breast cancer. Among three MoS-based nanomaterials, namely MoS nanospheres (NSs), MoS nanoflowers (NFs) and MoS quantum dots (QDs), MoS NSs possessed the highest PCE at 37.48%. In order to further improve the PCE, polyethyleneimine (PEI)-assisted photosensitizer IR820 decoration was carried out to prepare the MoS@PEI@IR820 (MPI) nanocomposite. The introduced IR820 not only improves PCE of the MoS nanomaterials to 47.08% by increasing the light absorption for enhancing PTT, but produces cytotoxic ROS for PDT, resulting in a combinational PTT/PDT with the multifunctional MPI. In addition, in vivo fluorescence (FL) bioimaging and infrared thermographic imaging have been achieved by the designed MPI nanoplatform, which has proven to be good biocompatibility, low toxicity and high PCE. This study provides a novel way for the design and construction of prominent theragnostic nanoagents for combinational PTT/PDT.

中文翻译：

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具有高光热转换效率的MoS2基纳米复合材料用于光热/光动力肿瘤联合治疗


光热转换效率（PCE）在肿瘤光热治疗（PTT）中起着至关重要的作用。在这项工作中，我们开发了一种基于MoS的抗肿瘤剂，通过尺寸/形态定制和IR820负载来提高光热转换效率，用于乳腺癌的光热/光动力组合治疗（PTT/PDT）。在三种MoS2基纳米材料中，即MoS2纳米球（NSs）、MoS2纳米花（NFs）和MoS2量子点（QDs），MoS2 NSs的PCE最高，为37.48%。为了进一步提高PCE，对聚乙烯亚胺（PEI）辅助光敏剂IR820进行修饰，制备了MoS@PEI@IR820（MPI）纳米复合材料。引入的IR820不仅通过增加光吸收来增强PTT，将MoS纳米材料的PCE提高到47.08%，而且还产生用于PDT的细胞毒性ROS，从而形成PTT/PDT与多功能MPI的组合。此外，所设计的MPI纳米平台还实现了体内荧光（FL）生物成像和红外热成像，并被证明具有良好的生物相容性、低毒性和高PCE。这项研究为设计和构建用于组合 PTT/PDT 的显着治疗诊断纳米药物提供了一种新方法。