A one-pot three-component method for the synthesis of 3-substituted 2- trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridin-3-yl analogues from 2-aminopyridine, substituted phenacyl bromides, and trifluoroacetaldehyde methyl hemiacetal (TFAMH) under solvent-free and the catalyst-free condition is described with good to excellent yield. This chemistry features the additive-free approach with the employment of safe, stable, and readily available starting materials with a wide substrate scope strategy.

中文翻译：

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新型三氟甲基二氢咪唑并[1, 2-a]吡啶的一锅法构建：一种更环保的方法

由2-氨基吡啶、取代苯甲酰溴和三氟乙醛甲基半缩醛一锅三组分合成3-取代2-三氟甲基-2,3-二氢咪唑并[1,2-a]吡啶-3-基类似物(TFAMH)在无溶剂和无催化剂条件下具有良好至优异的产率。该化学方法采用无添加剂方法，采用安全、稳定且易于获得的起始材料和广泛的底物范围策略。