Bisoprolol is a beta blocker used for the treatment of high blood pressure. During the synthesis and scale up of Bisoprolol, several related compounds will be generated. In this article we have disclosed a facile preparative access to the chemical synthesis of five related compounds of Bisoprolol, namely, 3,3′-((methylenebis(4,1-phenylene))bis(oxy))bis(1-(isopropylamino) propan-2-ol) (2),(Bisoprolol Ph.Eur impurity-C), 3,3′-(((oxybis(methylene))bis(4,1-phenylene)) bis(oxy))bis(1-(isopropyl amino)propan-2-ol) (3), (Bisoprolol Ph.Eur impurity-D), (±) 2-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-1-ol (4), (Bisoprolol Ph.Eur impurity-F), (±) 4-((3-isopropyl-2-oxooxazolidin-5-yl)methoxy)benzaldehyde (17) (Bisoprolol Ph.Eur impurity-T), (±) 5-((4-(hydroxymethyl)phenoxy)methyl)-3-isopropyloxazolidin-2-one (18) (Bisoprolol Ph.Eur impurity-U). These related compounds were listed in Pharmacopoeias and hence these impurities were synthesized and their structure was well established by modern analytical techniques like ¹H-NMR, ¹³C-NMR, HRMS. These synthetic methodologies will be useful in the future for the synthesis of other related compounds and analogues of the Bisoprolol.

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中文翻译：

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β-受体阻滞剂富马酸比索洛尔相关化合物的合成与表征

比索洛尔是一种用于治疗高血压的β受体阻滞剂。在比索洛尔的合成和放大过程中，会产生几种相关化合物。在本文中，我们公开了比索洛尔五种相关化合物的化学合成方法，即 3,3'-((亚甲基双(4,1-亚苯基))双(氧基))双(1-(异丙氨基) ) 丙-2-醇) (2),(比索洛尔 Ph.Eur 杂质-C), 3,3′-(((氧基双(亚甲基))双(4,1-亚苯基))双(氧基))双( 1-(异丙氨基)丙-2-醇) (3), (比索洛尔 Ph.Eur 杂质-D), (±) 2-(4-((2-异丙氧基乙氧基)甲基)苯氧基)-3-(异丙氨基) propan-1-ol (4), (比索洛尔 Ph.Eur 杂质-F), (±) 4-((3-异丙基-2-氧代恶唑烷-5-基)甲氧基)苯甲醛 (17) (比索洛尔 Ph.Eur 杂质) -T)，(±)5-((4-(羟甲基)苯氧基)甲基)-3-异丙基恶唑烷-2-酮(18)(比索洛尔Ph.Eur杂质-U)。^{这些相关化合物已列入药典，因此合成了这些杂质，并通过1} H-NMR、¹³ C-NMR、HRMS等现代分析技术确定了它们的结构。这些合成方法将来可用于合成其他相关化合物和比索洛尔类似物。

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