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The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2023-10-13 , DOI: 10.1016/j.biopha.2023.115720 Nieves Baenas 1 , Angélica Vega-García 2 , Joaquín Manjarrez-Marmolejo 3 , Diego A Moreno 4 , Iris A Feria-Romero 2
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2023-10-13 , DOI: 10.1016/j.biopha.2023.115720 Nieves Baenas 1 , Angélica Vega-García 2 , Joaquín Manjarrez-Marmolejo 3 , Diego A Moreno 4 , Iris A Feria-Romero 2
Affiliation
The aggressive and incurable diffuse gliomas constitute 80% of malignant brain tumors, and patients succumb to recurrent surgeries and drug resistance. Epidemiological research indicates that substantial consumption of fruits and vegetables diminishes the risk of developing this tumor type. Broccoli consumption has shown beneficial effects in both cancer and neurodegenerative diseases. These effects are partially attributed to the isothiocyanate sulforaphane (SFN), which can regulate the Keap1/Nrf2/ARE signaling pathway, stimulate detoxifying enzymes, and activate cellular antioxidant defense processes. This study employs a C6 rat glioma model to assess the chemoprotective potential of aqueous extracts from broccoli seeds, sprouts, and inflorescences, all rich in SFN, and pure SFN as positive control. The findings reveal that administering a dose of 100 mg/kg of broccoli sprout aqueous extract and 0.1 mg/kg of SFN to animals for 30 days before introducing 1 × 10 cells effectively halts tumor growth and progression. This study underscores the significance of exploring foods abundant in bioactive compounds, such as derivatives of broccoli, for potential preventive integration into daily diets. Using broccoli sprouts as a natural defense against cancer development might seem idealistic, yet this investigation establishes that administering this extract proves to be a valuable approach in designing strategies for glioma prevention. Although the findings stem from a rat glioma model, they offer promising insights for subsequent preclinical and clinical research endeavors.
中文翻译:
西兰花生物活性物质对癌症的预防作用:来自经过验证的大鼠神经胶质瘤模型的证据
侵袭性且无法治愈的弥漫性胶质瘤占恶性脑肿瘤的80%,患者死于反复手术和耐药性。流行病学研究表明,大量食用水果和蔬菜可以降低患这种肿瘤类型的风险。食用西兰花对癌症和神经退行性疾病都显示出有益的作用。这些作用部分归因于异硫氰酸萝卜硫素 (SFN),它可以调节 Keap1/Nrf2/ARE 信号通路、刺激解毒酶并激活细胞抗氧化防御过程。本研究采用 C6 大鼠神经胶质瘤模型来评估西兰花种子、豆芽和花序的水提取物的化学保护潜力,这些提取物均富含 SFN,并以纯 SFN 作为阳性对照。研究结果表明,在引入 1 × 10 个细胞之前,向动物施用 100 mg/kg 西兰花芽水提取物和 0.1 mg/kg SFN 剂量 30 天,可有效阻止肿瘤生长和进展。这项研究强调了探索富含生物活性化合物的食物(例如西兰花衍生物)的重要性,以将预防性纳入日常饮食中。使用西兰花芽作为对抗癌症发展的天然防御措施似乎很理想化,但这项研究表明,施用这种提取物被证明是设计神经胶质瘤预防策略的一种有价值的方法。尽管这些发现源于大鼠神经胶质瘤模型,但它们为后续的临床前和临床研究工作提供了有希望的见解。
更新日期:2023-10-13
中文翻译:
西兰花生物活性物质对癌症的预防作用:来自经过验证的大鼠神经胶质瘤模型的证据
侵袭性且无法治愈的弥漫性胶质瘤占恶性脑肿瘤的80%,患者死于反复手术和耐药性。流行病学研究表明,大量食用水果和蔬菜可以降低患这种肿瘤类型的风险。食用西兰花对癌症和神经退行性疾病都显示出有益的作用。这些作用部分归因于异硫氰酸萝卜硫素 (SFN),它可以调节 Keap1/Nrf2/ARE 信号通路、刺激解毒酶并激活细胞抗氧化防御过程。本研究采用 C6 大鼠神经胶质瘤模型来评估西兰花种子、豆芽和花序的水提取物的化学保护潜力,这些提取物均富含 SFN,并以纯 SFN 作为阳性对照。研究结果表明,在引入 1 × 10 个细胞之前,向动物施用 100 mg/kg 西兰花芽水提取物和 0.1 mg/kg SFN 剂量 30 天,可有效阻止肿瘤生长和进展。这项研究强调了探索富含生物活性化合物的食物(例如西兰花衍生物)的重要性,以将预防性纳入日常饮食中。使用西兰花芽作为对抗癌症发展的天然防御措施似乎很理想化,但这项研究表明,施用这种提取物被证明是设计神经胶质瘤预防策略的一种有价值的方法。尽管这些发现源于大鼠神经胶质瘤模型,但它们为后续的临床前和临床研究工作提供了有希望的见解。