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The emerging role of PANoptosis in cancer treatment
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2023-10-12 , DOI: 10.1016/j.biopha.2023.115696
Yongai Xiong 1
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2023-10-12 , DOI: 10.1016/j.biopha.2023.115696
Yongai Xiong 1
Affiliation
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Programmed cell death (PCD) is a key mechanism for the study of anticancer drugs and has a significant impact on the development and management of cancer. A growing amount of data indicates that different kinds of PCD, particularly pyroptosis, apoptosis, and necroptosis, interact closely. Recent research has revealed the existence of the distinct inflammatory PCD modality known as PANoptosis, which is controlled by complex PANoptosome complexes built by combining elements from different PCD pathways. No single PCD route is sufficient to explain all of the physiologic effects seen in PANoptosis. Numerous studies have demonstrated that PANoptosis can successfully stop cancer cells from growing, proliferating, and developing drug resistance. As a result, it has changed the focus of targeted anticancer therapy. In this review, we outlined the molecular processes of PANoptosis activation and modulation as well as the mechanisms of innate immune cell death. In order to provide a theoretical foundation for the development of drugs targeting PANoptosis as an anti-cancer target, we also highlight the PANoptosomes discovered to date and give an overview of the implications of PANoptosis in cancer treatment.
中文翻译:
PANoptosis 在癌症治疗中的新作用
程序性细胞死亡 (PCD) 是抗癌药物研究的关键机制,对癌症的发生和管理有重大影响。越来越多的数据表明,不同种类的 PCD,特别是细胞焦亡、细胞凋亡和坏死性凋亡,相互作用密切。最近的研究揭示了称为 PANoptosis 的独特炎性 PCD 模式的存在,它由通过组合来自不同 PCD 通路的元件构建的复杂 PANoptosome 复合物控制。没有单一的 PCD 途径足以解释 PANoptosis 中观察到的所有生理效应。大量研究表明,PANoptosis 可以成功阻止癌细胞生长、增殖和产生耐药性。因此,它改变了靶向抗癌治疗的重点。在这篇综述中,我们概述了 PANoptosis 激活和调节的分子过程以及先天免疫细胞死亡的机制。为了为开发以 PANoptosis 作为抗癌靶点的药物提供理论基础,我们还重点介绍了迄今为止发现的 PANoptosomes,并概述了 PANoptosis 在癌症治疗中的作用。
更新日期:2023-10-12
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
PANoptosis 在癌症治疗中的新作用
程序性细胞死亡 (PCD) 是抗癌药物研究的关键机制,对癌症的发生和管理有重大影响。越来越多的数据表明,不同种类的 PCD,特别是细胞焦亡、细胞凋亡和坏死性凋亡,相互作用密切。最近的研究揭示了称为 PANoptosis 的独特炎性 PCD 模式的存在,它由通过组合来自不同 PCD 通路的元件构建的复杂 PANoptosome 复合物控制。没有单一的 PCD 途径足以解释 PANoptosis 中观察到的所有生理效应。大量研究表明,PANoptosis 可以成功阻止癌细胞生长、增殖和产生耐药性。因此,它改变了靶向抗癌治疗的重点。在这篇综述中,我们概述了 PANoptosis 激活和调节的分子过程以及先天免疫细胞死亡的机制。为了为开发以 PANoptosis 作为抗癌靶点的药物提供理论基础,我们还重点介绍了迄今为止发现的 PANoptosomes,并概述了 PANoptosis 在癌症治疗中的作用。