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Electrochemical trifluoroalkylation/annulation for the synthesis of CF3-functionalized tetrahydroquinolines and dihydroquinolinones
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2023-10-14 , DOI: 10.1039/d3ob00987d
Hao-Zeng Wu 1 , Zhong-Shan Teng 1 , Yu-Xin Ke 1 , Yu Zou 1 , Ping Gao 1 , Yue Li 1 , Cheng-He Zhou 1 , Zhong-Lin Zang 1
Affiliation  

Tuning the electronic structure of protecting groups on the nitrogen atom of substrates has emerged as an effective strategy to achieve the tandem trifluoromethylation/C(sp2)–H annulation using Langlois’ reagent as the CF3 source for the electrochemical synthesis of functionalized tetrahydroquinolines and dihydroquinolinones.

中文翻译:

用于合成CF3官能化四氢喹啉和二氢喹啉酮的电化学三氟烷基化/环化

调整底物氮原子上保护基的电子结构已成为一种有效的策略,以使用 Langlois 试剂作为 CF 3源实现串联三氟甲基化/C(sp 2 ) –H 成环,用于电化学合成功能化四氢喹啉和二氢喹啉酮类。
更新日期:2023-10-19
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