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A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2023-10-13 , DOI: 10.1039/d3qm00842h Wei Zhao 1 , Chao Fu 1 , Hanyi Gao 2 , Yizhao Zhou 3 , Caihong Yan 4 , Yuli Yin 1 , Rong Hu 1 , Ben Zhong Tang 5
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2023-10-13 , DOI: 10.1039/d3qm00842h Wei Zhao 1 , Chao Fu 1 , Hanyi Gao 2 , Yizhao Zhou 3 , Caihong Yan 4 , Yuli Yin 1 , Rong Hu 1 , Ben Zhong Tang 5
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Ultrasound-triggered sonodynamic therapy (SDT) presents growing promise in deep-seated or unresectable tumor inhibition because of the perfect tissue penetration ability. However, its therapeutic efficacy is always restricted by the limited reactive oxygen species (ROS) generation ability of sonosensitizers. In this work, based on molecular engineering, we have fabricated aggregation-induced emission (AIE)-active organic sonosensitizers bearing efficient ROS generation with US irradiation for tumor treatment. By enhancing the intramolecular charge transfer strength and intermolecular interaction, an organic sonosensitizer with reduced energy gap and AIE features was developed, presenting enhanced oxygen sensitization behavior to produce ROS upon an ultrasound trigger compared to Ce 6. Moreover, the excellent mitochondrial enrichment of the obtained sonosensitizer enables effective tumor cell eradication via apoptotic and ferroptosis pathways with ultrasound irradiation. The efficient in vivo tumor inhibition was also achieved based on the SDT approach. Therefore, this work provided a generalized and promising strategy for deep-seated or unresectable tumor treatment in the clinic.
中文翻译：
一种高性能 AIE 活性声敏剂，用于有效的声动力肿瘤治疗
超声触发声动力疗法（SDT）由于其完美的组织穿透能力，在深层或不可切除的肿瘤抑制方面呈现出越来越大的前景。然而，其治疗效果始终受到声敏剂有限的活性氧（ROS）生成能力的限制。在这项工作中，基于分子工程，我们制造了聚集诱导发射（AIE）活性有机声敏剂，在超声照射下可有效产生ROS，用于肿瘤治疗。通过增强分子内电荷转移强度和分子间相互作用，开发了一种具有减小能隙和AIE特性的有机声敏剂，与Ce 6 相比，其在超声触发下表现出增强的氧敏化行为以产生ROS。此外，所得产物具有优异的线粒体富集性声敏剂能够通过超声波照射的细胞凋亡和铁死亡途径有效地根除肿瘤细胞。基于SDT方法还实现了有效的体内肿瘤抑制。因此，这项工作为临床上深部或不可切除肿瘤的治疗提供了一种通用且有前景的策略。
更新日期：2023-10-13
中文翻译：
一种高性能 AIE 活性声敏剂，用于有效的声动力肿瘤治疗
超声触发声动力疗法（SDT）由于其完美的组织穿透能力，在深层或不可切除的肿瘤抑制方面呈现出越来越大的前景。然而，其治疗效果始终受到声敏剂有限的活性氧（ROS）生成能力的限制。在这项工作中，基于分子工程，我们制造了聚集诱导发射（AIE）活性有机声敏剂，在超声照射下可有效产生ROS，用于肿瘤治疗。通过增强分子内电荷转移强度和分子间相互作用，开发了一种具有减小能隙和AIE特性的有机声敏剂，与Ce 6 相比，其在超声触发下表现出增强的氧敏化行为以产生ROS。此外，所得产物具有优异的线粒体富集性声敏剂能够通过超声波照射的细胞凋亡和铁死亡途径有效地根除肿瘤细胞。基于SDT方法还实现了有效的体内肿瘤抑制。因此，这项工作为临床上深部或不可切除肿瘤的治疗提供了一种通用且有前景的策略。
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