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5-Bromo-3,4-dihydroxybenzaldehyde stabilizes diabetic retinal neurovascular units by inhibiting the inflammatory microenvironment
Biomedicine & Pharmacotherapy ( IF 6.9 ) Pub Date : 2023-10-13 , DOI: 10.1016/j.biopha.2023.115657
Qionghua Wang 1 , Lanyue Zhang 1 , Qiang Shen 1 , Chunqin Zeng 1 , Yanhong Fang 1 , Kepeng Ou 2
Affiliation  

Diabetic retinopathy (DR) is a leading cause of blindness characterized by damage to the retinal neurovascular unit, which is caused by hyperglycemia-induced metabolic and inflammatory responses. 5-Bromo-3,4-dihydroxybenzaldehyde (BDB) is a compound derived from marine red algae and known for its anti-inflammatory effects. This study aimed to investigate the potential protective effects of BDB on DR using primary human retinal vascular endothelial cells and retinal tissue explants. The analysis involved assessing vascular integrity, expression of tight junction protein, hyperglycemia-induced permeability, and retinal ganglion cell (RGC) apoptosis. The protective effect of BDB in maintaining the diabetic retinal neurovascular units was verified using type 1 diabetic mouse models. Additionally, the inhibitory effect of BDB on the levels of inflammatory cytokines TNF-α, IL-1β, and IL-6 were examined. experiments revealed that BDB promoted vascular integrity, inhibited the transcription of pro-inflammatory factors, and alleviated hyperglycemia-induced permeability. BDB also protected RGC from hyperglycemia-induced apoptosis. In diabetic mice models, BDB treatment maintained the integrity of diabetic retinal neurovascular units and inhibited the secretion of TNF-α, IL-1β, and IL-6. BDB demonstrated a protective effect on DR by inhibiting the secretion of inflammatory factors, suggesting its potential as a therapeutic agent for the treatment of DR. Further research is warranted to validate its safety and efficacy for clinical application.

中文翻译:

5-溴-3,4-二羟基苯甲醛通过抑制炎症微环境来稳定糖尿病视网膜神经血管单位

糖尿病视网膜病变(DR)是导致失明的主要原因,其特征是视网膜神经血管单位受损,这是由高血糖引起的代谢和炎症反应引起的。 5-溴-3,4-二羟基苯甲醛 (BDB) 是一种源自海洋红藻的化合物,以其抗炎作用而闻名。本研究旨在利用原代人视网膜血管内皮细胞和视网膜组织外植体研究 BDB 对 DR 的潜在保护作用。分析涉及评估血管完整性、紧密连接蛋白的表达、高血糖诱导的通透性和视网膜神经节细胞(RGC)凋亡。使用 1 型糖尿病小鼠模型验证了 BDB 对维持糖尿病视网膜神经血管单位的保护作用。此外,还检测了 BDB 对炎症细胞因子 TNF-α、IL-1β 和 IL-6 水平的抑制作用。实验表明,BDB 促进血管完整性,抑制促炎因子的转录,并减轻高血糖引起的通透性。 BDB 还可以保护 RGC 免受高血糖诱导的细胞凋亡。在糖尿病小鼠模型中,BDB 治疗维持了糖尿病视网膜神经血管单位的完整性,并抑制了 TNF-α、IL-1β 和 IL-6 的分泌。 BDB 通过抑制炎症因子的分泌对 DR 具有保护作用,表明其作为治疗 DR 的治疗剂的潜力。需要进一步的研究来验证其临床应用的安全性和有效性。
更新日期:2023-10-13
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