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S1PR1通过PDK1-LATS1/2-YAP通路调节卵巢癌细胞衰老
Oncogene ( IF 6.9 ) Pub Date : 2023-10-12 , DOI: 10.1038/s41388-023-02853-w
Yi-Ping Tao 1 , Heng-Yan Zhu 1 , Qian-Yuan Shi 1 , Cai-Xia Wang 1 , Yu-Xin Hua 1, 2 , Han-Yin Hu 1, 2 , Qi-Yin Zhou 1, 2 , Zi-Lu Zhou 1 , Ying Sun 1 , Xiao-Min Wang 1 , Yu Wang 1 , Ya-Ling Zhang 1 , Yan-Jun Guo 1 , Zi-Ying Wang 1 , Xuan Che 3 , Chun-Wei Xu 4 , Xian-Chao Zhang 5 , Michal Heger 6, 7, 8 , Su-Ping Tao 9 , Xin Zheng 9 , Ying Xu 1 , Lei Ao 1 , Ai-Jun Liu 10 , Sheng-Bing Liu 1 , Shu-Qun Cheng 11 , Wei-Wei Pan 1, 12
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更新日期:2023-10-14
Oncogene ( IF 6.9 ) Pub Date : 2023-10-12 , DOI: 10.1038/s41388-023-02853-w
Yi-Ping Tao 1 , Heng-Yan Zhu 1 , Qian-Yuan Shi 1 , Cai-Xia Wang 1 , Yu-Xin Hua 1, 2 , Han-Yin Hu 1, 2 , Qi-Yin Zhou 1, 2 , Zi-Lu Zhou 1 , Ying Sun 1 , Xiao-Min Wang 1 , Yu Wang 1 , Ya-Ling Zhang 1 , Yan-Jun Guo 1 , Zi-Ying Wang 1 , Xuan Che 3 , Chun-Wei Xu 4 , Xian-Chao Zhang 5 , Michal Heger 6, 7, 8 , Su-Ping Tao 9 , Xin Zheng 9 , Ying Xu 1 , Lei Ao 1 , Ai-Jun Liu 10 , Sheng-Bing Liu 1 , Shu-Qun Cheng 11 , Wei-Wei Pan 1, 12
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细胞衰老会阻止各种癌基因的激活。因此,诱导衰老是干扰肿瘤细胞重要过程的潜在有效策略。1-磷酸鞘氨醇受体 1 (S1PR1) 与多种癌症类型有关,包括卵巢癌。S1PR1 调节卵巢癌细胞衰老的机制目前尚不清楚。在这项研究中,我们证明S1PR1在人卵巢癌组织和细胞系中高表达。S1PR1缺失抑制卵巢癌细胞的增殖和迁移。S1PR1缺失促进卵巢癌细胞衰老并使卵巢癌细胞对顺铂化疗敏感。卵巢癌细胞暴露于 1-磷酸鞘氨醇 (S1P) 会增加 3-磷脂酰肌醇依赖性蛋白激酶 1 (PDK1) 的表达,降低大肿瘤抑制因子 1/2 (LATS1/2) 的表达,并诱导Yes相关蛋白(p-YAP)。在药物抑制后,S1PR1 敲除细胞中获得了相反的结果。在 S1PR1 缺陷的卵巢癌细胞中沉默 LATS1/2 后,衰老受到抑制,并且 S1PR1 表达随着 YAP 表达而增加。通过染色质免疫沉淀证实了 YAP 对 S1PR1 的转录调节。因此,S1PR1-PDK1-LATS1/2-YAP 通路通过 YAP 介导的反馈回路调节卵巢癌细胞衰老。S1PR1 构成了诱导卵巢癌细胞衰老的药物靶标。对 S1PR1-PDK1-LATS1/2-YAP 信号轴的药物干预可能会增强标准化疗的疗效。
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