In the 160 years since Rudolf Virchow first postulated that neoplasia arises by the same law that regulates embryonic development, scientists have come to recognize the striking overlap between the molecular and cellular programs used by cancers and embryos. Advances in cancer biology and molecular techniques have further highlighted the similarities between carcinogenesis and embryogenesis, where cellular growth, differentiation, motility, and intercellular cross talk are mediated by common drivers and regulatory networks. This review highlights the many connections linking cancer biology and developmental biology to provide a deeper understanding of how a tissue's developmental history may both enable and constrain cancer cell evolution.

中文翻译：

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癌症作为一种发育疾病出了问题


自从 Rudolf Virchow 首次假设肿瘤是由调节胚胎发育的相同规律引起的 160 年里，科学家们已经开始认识到癌症和胚胎使用的分子和细胞程序之间的惊人重叠。癌症生物学和分子技术的进步进一步突出了致癌作用和胚胎发生之间的相似性，其中细胞生长、分化、运动和细胞间串扰是由共同的驱动因素和调节网络介导的。本综述强调了将癌症生物学和发育生物学联系起来的许多联系，以更深入地了解组织的发育历史如何促进和限制癌细胞进化。