Gliomas are a diverse group of primary central nervous system tumors that affect both children and adults. Recent studies have revealed a dynamic cross talk that occurs between glioma cells and components of their microenvironment, including neurons, astrocytes, immune cells, and the extracellular matrix. This cross talk regulates fundamental aspects of glioma development and growth. In this review, we discuss recent discoveries about the impact of these interactions on gliomas and highlight how tumor cells actively remodel their microenvironment to promote disease. These studies provide a better understanding of the interactions in the microenvironment that are important in gliomas, offer insight into the cross talk that occurs, and identify potential therapeutic vulnerabilities that can be utilized to improve clinical outcomes.

中文翻译：

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微环境在胶质瘤发病机制中的作用


神经胶质瘤是一组不同的原发性中枢神经系统肿瘤，影响儿童和成人。最近的研究揭示了神经胶质瘤细胞与其微环境成分（包括神经元、星形胶质细胞、免疫细胞和细胞外基质）之间发生的动态串扰。这种串扰调节胶质瘤发展和生长的基本方面。在这篇综述中，我们讨论了关于这些相互作用对神经胶质瘤影响的最新发现，并强调了肿瘤细胞如何积极重塑其微环境以促进疾病。这些研究可以更好地了解微环境中对神经胶质瘤中重要的相互作用，提供对发生的串扰的见解，并确定可用于改善临床结果的潜在治疗脆弱性。