Atorvastatin, a lipid-lowering drug that is widely used in the treatment of cardiovascular diseases, has significant clinical significance. This article focuses on the synthetic procedures of atorvastatin, including Paal-Knorr synthesis and several new synthetic strategies. It also outlines chemical and chemo-enzymatic methods for synthesizing optically active side chain of atorvastatin. In addition, a comprehensive overview of the analytical monitoring techniques for atorvastatin and its metabolites and impurities is reported, alongside a discussion of their strengths and limitations.

中文翻译：

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阿托伐他汀及其中间体的合成与分析研究进展


阿托伐他汀是一种广泛用于治疗心血管疾病的降脂药物，具有重要的临床意义。本文重点介绍阿托伐他汀的合成流程，包括Paal-Knorr合成法和几种新的合成策略。它还概述了合成阿托伐他汀光学活性侧链的化学和化学酶方法。此外，还报告了阿托伐他汀及其代谢物和杂质的分析监测技术的全面概述，并讨论了其优点和局限性。