6,6-Dimethyl-3-azabicyclo[3.1.0]hexane (6,6-DMABH) is a crucial component in several antiviral medications, such as boceprevir and pf-07321332. To enable more efficient synthesis of 6,6-DMABH, we have developed an innovative approach that utilizes intramolecular cyclopropanation of alpha-diazoacetates via Ru (II) catalysis and the Gabriel synthesis. Gram-scale synthesis of 6,6-DMABH from 3-methyl-2-butenol is achieved in seven distinct steps, resulting in a total yield of 28%.

中文翻译：

---

Ru(II)催化分子内环丙烷化合成6,6-二甲基-3-氮杂双环[3.1.0]己烷

6,6-二甲基-3-氮杂双环[3.1.0]己烷 (6,6-DMABH) 是多种抗病毒药物的重要成分，例如 boceprevir 和 pf-07321332。为了更有效地合成 6,6-DMABH，我们开发了一种创新方法，通过Ru (II) 催化和 Gabriel 合成利用 α-重氮乙酸酯的分子内环丙烷化。由 3-甲基-2-丁烯醇合成 6,6-DMABH 的克级合成通过七个不同的步骤实现，总产率为 28%。