DNA水凝胶作为功能材料及其生物医学应用,Advanced Functional Materials

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DNA水凝胶作为功能材料及其生物医学应用
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-10-12 , DOI: 10.1002/adfm.202309070
Yinzhou Ma _{1,

2} , Xiaocen Duan ₁ , Jianyong Huang ₁

Affiliation

随着 DNA 纳米技术的显着发展，人们对 DNA 分子的兴趣已经从其生物学作用扩展到材料科学的构建模块。作为DNA基材料的一个独特分支，DNA水凝胶表现出许多令人着迷的特性，包括广泛的生物相容性、精确的可编程性、方便的修饰和可调节的机械性能，这使得DNA水凝胶成为理想的生物材料。此外，通过与功能性核酸（如适体、i-motif纳米结构、CpG寡脱氧核苷酸和DNA酶）结合，DNA水凝胶可以进一步定制以提供额外的靶标识别、治疗潜力和催化活性，使其在生物传感和医疗应用。这篇综述旨在为读者提供生物医学 DNA 水凝胶重要进展的最新概述。首先，介绍了利用DNA作为水凝胶网络中的建筑材料和功能单元的水凝胶的不同合成策略，并讨论了它们在生物医学应用中的优势。随后重点介绍了近年来生物医学DNA水凝胶的新方法和新应用，如治疗系统、细胞培养平台、组织工程材料和生物传感器。最后，提出了 DNA 水凝胶在生物医学领域的未来前景和仍然面临的挑战。

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DNA Hydrogels as Functional Materials and Their Biomedical Applications

With the remarkable development of DNA nanotechnology, interest in DNA molecules has expanded beyond its biological role to building blocks in materials science. As a unique branch of DNA-based materials, DNA hydrogels have exhibited many fascinating characteristics, including broad biocompatibility, precise programmability, convenient modification, and tunable mechanical properties, which make DNA hydrogels ideal biomaterials. Moreover, by combining with functional nucleic acids, such as aptamers, i-motif nanostructures, CpG oligodeoxynucleotides, and DNAzymes, DNA hydrogels can be further tailored to provide additional target recognition, therapeutic potential, and catalytic activities, allowing them to play important roles in biosensing and medical applications. This review, aims to provide readers with an up-to-date overview of the important developments of biomedical DNA hydrogels. First, it introduces different synthetic strategies of hydrogels that utilize DNA as building materials and functional units within the hydrogel networks and discuss their advantages in biomedical applications. Subsequently, new approaches and applications of biomedical DNA hydrogels in the recent years are highlighted, such as therapeutic systems, cell culture platforms, tissue engineering materials, and biosensors. Finally, future perspectives and remaining challenges of DNA hydrogels in biomedicine are presented.

更新日期：2023-10-12

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