载氧酸响应 Cu/ZIF-8 用于光动力抗菌治疗致龋链球菌感染,Dalton Transactions

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载氧酸响应 Cu/ZIF-8 用于光动力抗菌治疗致龋链球菌感染
Dalton Transactions ( IF 3.5 ) Pub Date : 2023-10-13 , DOI: 10.1039/d3dt02816j
Ruifeng Wang _{1,

2} , Qiyuan Pan ₁ , Fang Li ₁ , Jingying Guo ₁ , Yaru Huo ₁ , Chao Xu ₁ , Manwen Xiong ₁ , Ziyong Cheng ₃ , Min Liu ₁ , Jun Lin ₄

Affiliation

酸脱矿导致的龋齿是最常见的口腔微生物感染性疾病。由于口腔内操作空间狭小且复杂，彻底清除变形链球菌（S. mutans）和其他致龋菌具有挑战性。_{O 2} -Cu/ZIF-8@Ce6/ZIF-8@HA (OCZCH)作为一种智能酸响应性光敏纳米材料，能够适应厌氧和酸性微环境，从而灭活变形链球菌。在这项工作中，OCZCH 不仅在 SEM 和 TEM 图像中表现出规则的纳米形态，而且还表现出智能的酸响应性，如 Ce6 和氧气的释放所证明。当受到 650 nm 近红外光激发时，Ce6 会释放出活性氧 (ROS)，与体内氧气协同作用，显着增强光动力疗法 (PDT) 的抗菌治疗效果。体外抗菌实验表明，OCZCH 对变形链球菌和生物膜具有良好的杀菌效果。值得注意的是，细菌的产酸能力也受到显着抑制。凭借其载氧光敏特性、对酸性环境的优异响应性以及厌氧条件下的抗菌能力，OCZCH被认为是临床应用治疗龋齿的创新候选者。

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Oxygen-carrying acid-responsive Cu/ZIF-8 for photodynamic antibacterial therapy against cariogenic Streptococcus mutans infection

Caries as a result of acid demineralization is the most common oral microbial infectious disease. Due to the small and complex intraoral operating space, it is challenging to completely remove Streptococcus mutans (S. mutans) and other cariogenic bacteria. As an intelligent acid-responsive photosensitive nanomaterial, O₂-Cu/ZIF-8@Ce6/ZIF-8@HA (OCZCH) was chosen to adapt to the anaerobic and acidic microenvironment for inactivating S. mutans. In this work, OCZCH not only exhibits a regular nanomorphology in SEM and TEM images but also shows intelligent acid responsiveness as evidenced by the release of Ce6 and oxygen. When excited by near-infrared light at 650 nm, Ce6 releases reactive oxygen species (ROS) that act synergistically with internal oxygen to significantly enhance the antimicrobial therapeutic effect of photodynamic therapy (PDT). In vitro antimicrobial experiments showed that OCZCH could achieve an impressive sterilization effect against S. mutans and biofilm. Notably, the acid-producing ability of the bacteria was also significantly inhibited. With its oxygen-carrying photosensitizing properties, excellent responsiveness to acidic environments, and antimicrobial capacity under anaerobic conditions, OCZCH is considered an innovative candidate for clinical application in treating dental caries.

更新日期：2023-10-13

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